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135459-87-9

135459-87-9 structural image
Product Name: Strontium ranelate
Formula: C12H12N2O8SSr
Synonyms: 2-[N,N-Di(carboxymethyl)amino]-3-cyano-4-carboxymethylthiophene-5-carboxylic acid strontium salt;5-[Bis(carboxymethyl)amino]-2-carboxy-4-cyano-3-thiopheneacetic acid, strontium salt;Distrontium renelate;Ranelic acid strontium salt
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SAFETY INFORMATION

Signal word Warning
Pictogram(s)

Exclamation Mark
Irritant
GHS07
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

COMPUTED DESCRIPTORS

Molecular Weight 513.5 g/mol
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 11
Rotatable Bond Count 4
Exact Mass 513.7957108 g/mol
Monoisotopic Mass 513.7957108 g/mol
Topological Polar Surface Area 216 Ų
Heavy Atom Count 25
Formal Charge 0
Complexity 533
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 3
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Strontium ranelate, a strontium (II) salt of ranelic acid, is a medication for osteoporosis. Some reports have shown that strontium ranelate can slow down the progression of osteoarthritis of the knee. This agent presents an atypical mechanism of action in which it increases deposition of new bone by osteoblasts and, simultaneously, reduces the resorption of bone by osteoclasts. It is therefore promoted as a "dual action bone agent" (DABA) indicated for use in treatment of severe osteoporosis. Furthermore, various clinical studies demonstrate the ability of strontium ranelate to improve and strengthen intrinsic bone tissue quality and microarchitecture in osteoporosis by way of a number of cellular and microstructural changes by which anti-fracture efficacy is enhanced. Available for prescription use for a time in some parts of the world as Protelos (strontium ranelate) 2 g granules for oral suspension by Servier, it was ultimately discontinued in 2016-2017 owing to an increased adverse cardiac effects profile along with increased risk of venous thromboembolism (VTE) and various life threatening allergic reactions.

RELATED SUPPLIERS

Dishman Carbogen Amcis Ltd (Dishman Group)

1Y
product:135459-87-9 Strontium ranelate 98%

Ralington Pharma

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product:135459-87-9 98%

BDR Pharmaceuticals International Pvt Ltd

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product:Strontium ranelate 98%

Cadchem Laboratories Limited

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product:Strontium ranelate 135459-87-9 98%

Suntril Pharmaceuticals Pvt Ltd

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product:135459-87-9 Strontium ranelate 98%

Maithri Drugs Pvt Ltd

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product:Strontium ranelate 135459-87-9 98%
All suppliers(6)