CHEMICAL AND PHYSICAL PROPERTIES
| Density | 1.088 g/mL at 37 °C |
|---|---|
| Viscosity | 2.32 mPa.s at 37 °C |
| pH | pH: 6-8 |
| Other Experimental Properties | Amphiphilic |
COMPUTED DESCRIPTORS
| Molecular Weight | 725.7 g/mol |
|---|---|
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 14 |
| Rotatable Bond Count | 15 |
| Exact Mass | 726.07603 g/mol |
| Monoisotopic Mass | 726.07603 g/mol |
| Topological Polar Surface Area | 220 Ų |
| Heavy Atom Count | 40 |
| Formal Charge | 0 |
| Complexity | 712 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 4 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Gadoxetate Disodium is a paramagnetic contrast agent consisting of the disodium salt of the gadolinium ion chelated with the lipophilic moiety ethoxybenzyl (EOB) bound to diethylenetriamine pentaacetic acid (DTPA). When placed in a magnetic field, gadolinium produces a large magnetic moment and so a large local magnetic field, which can enhance the relaxation rate of nearby protons; as a result, the signal intensity of tissue images observed with magnetic resonance imaging (MRI) may be enhanced. Because this agent is preferentially taken up by normal functioning hepatocytes, normal hepatic tissue is enhanced with MRI while tumor tissue is unenhanced. In addition, because this agent is excreted in the bile, it may be used to visualize the biliary system using MRI.