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129-20-4

129-20-4 structural image
Product Name: OXYPHENYL BUTAZONE
Formula: C19H20N2O3
Synonyms: 4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione;p-Hydroxyphenylbutazone;p-Oxyphenylbutazone;
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CHEMICAL AND PHYSICAL PROPERTIES

Color/Form WHITE TO YELLOWISH WHITE, CRYSTALLINE POWDER
Odor ODORLESS
Melting Point 96 °C
Solubility 60 mg/L (at 30 °C)
LogP 2.72
LogS -3.73
Collision Cross Section 177.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

SAFETY INFORMATION

Signal word Warning
Pictogram(s)

Exclamation Mark
Irritant
GHS07

Environment
GHS09
GHS Hazard Statements H302:Acute toxicity,oral
H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes P273:Avoid release to the environment.

COMPUTED DESCRIPTORS

Molecular Weight 324.4 g/mol
XLogP3 2.7
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 3
Rotatable Bond Count 5
Exact Mass 324.14739250 g/mol
Monoisotopic Mass 324.14739250 g/mol
Topological Polar Surface Area 60.8 Ų
Heavy Atom Count 24
Formal Charge 0
Complexity 454
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Oxyphenbutazone is a metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following association with blood dyscrasis and Stevens-Johnson syndrome. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, a gout suppressant, a drug metabolite, a xenobiotic metabolite, an antineoplastic agent and an antimicrobial agent. It is a member of pyrazolidines and a member of phenols. It is functionally related to a phenylbutazone.