COMPUTED DESCRIPTORS
| Molecular Weight | 7127 g/mol |
|---|---|
| XLogP3 | -13.7 |
| Hydrogen Bond Donor Count | 40 |
| Hydrogen Bond Acceptor Count | 167 |
| Rotatable Bond Count | 176 |
| Exact Mass | 7124.2829700 g/mol |
| Monoisotopic Mass | 7122.2762603 g/mol |
| Topological Polar Surface Area | 2860 Ų |
| Heavy Atom Count | 457 |
| Formal Charge | 0 |
| Complexity | 19100 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 72 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
An antisense oligonucleotide that induces survival motor neuron (SMN) protein expression, it was approved by the U.S. FDA in December, 2016 as Spinraza for the treatment of children and adults with spinal muscular atrophy (SMA). It is adminstrated as direct intrathecal injection.