125692-40-2
Product Name:
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
Formula:
C121H168N26O33S4
Synonyms:
ET-3
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COMPUTED DESCRIPTORS
| Molecular Weight | 2643.1 g/mol |
|---|---|
| XLogP3 | -4.3 |
| Hydrogen Bond Donor Count | 34 |
| Hydrogen Bond Acceptor Count | 41 |
| Rotatable Bond Count | 49 |
| Exact Mass | 2642.1183514 g/mol |
| Monoisotopic Mass | 2641.1149966 g/mol |
| Topological Polar Surface Area | 1060 Ų |
| Heavy Atom Count | 184 |
| Formal Charge | 0 |
| Complexity | 5720 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 25 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
A 21-amino acid peptide that circulates in the plasma, but its source is not known. Endothelin-3 has been found in high concentrations in the brain and may regulate important functions in neurons and astrocytes, such as proliferation and development. It also is found throughout the gastrointestinal tract and in the lung and kidney. (N Eng J Med 1995;333(6):356-63)