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122332-18-7

122332-18-7 structural image
Product Name: Mivobulin
Formula: C17H19N5O2
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COMPUTED DESCRIPTORS

Molecular Weight 325.4 g/mol
XLogP3 2.4
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 4
Exact Mass 325.15387487 g/mol
Monoisotopic Mass 325.15387487 g/mol
Topological Polar Surface Area 102 Ų
Heavy Atom Count 24
Formal Charge 0
Complexity 478
Isotope Atom Count 0
Defined Atom Stereocenter Count 1
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Mivobulin is a synthetic, colchicine analogue with potential antineoplastic activity. Mivobulin targets and binds to colchicine-binding site on tubulin, thereby inhibiting microtubule polymerization, the assembly of the mitotic spindle and mitosis. This eventually results in cell cycle arrest, apoptosis and a reduction in cellular proliferation.