120-97-8
Product Name:
DICHLORPHENAMIDE
Formula:
C6H6Cl2N2O4S2
Synonyms:
4,5-Dichloro-1,3-benzenedisulfonamide;Diclofenamide
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
| Physical Description | Solid |
|---|---|
| Color/Form | NEEDLES FROM DIMETHYLSULFOXIDE + WATER |
| Odor | SLIGHT CHARACTERISTIC ODOR |
| Melting Point | 228.5 |
| Solubility | PRACTICALLY INSOL IN WATER; SOL IN ALKALINE SOLN |
| LogP | 0.2 |
| Dissociation Constants | PKA: 7.4, KA: 8.6 |
COMPUTED DESCRIPTORS
| Molecular Weight | 305.2 g/mol |
|---|---|
| XLogP3 | 0.3 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 2 |
| Exact Mass | 303.9146044 g/mol |
| Monoisotopic Mass | 303.9146044 g/mol |
| Topological Polar Surface Area | 137 Ų |
| Heavy Atom Count | 16 |
| Formal Charge | 0 |
| Complexity | 452 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Diclofenamide is a sulfonamide that is benzene-1,3-disulfonamide in which the hydrogens at positions 4 and 5 are substituted by chlorine. An oral carbonic anhydrase inhibitor, it partially suppresses the secretion (inflow) of aqueous humor in the eye and so reduces intraocular pressure. It is used for the treatment of glaucoma. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor, an antiglaucoma drug and an ophthalmology drug. It is a sulfonamide and a dichlorobenzene.