116-38-1
Product Name:
Edrophonium chloride
Formula:
C10H16ClNO
Synonyms:
Ethyl(m-hydroxyphenyl)dimethylammonium chloride
Inquiry
CHEMICAL AND PHYSICAL PROPERTIES
Solubility | >30.3 [ug/mL] (The mean of the results at pH 7.4) |
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Collision Cross Section | 135.7 Ų [M]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards] |
COMPUTED DESCRIPTORS
Molecular Weight | 201.69 g/mol |
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Hydrogen Bond Donor Count | 1 |
Hydrogen Bond Acceptor Count | 2 |
Rotatable Bond Count | 2 |
Exact Mass | 201.0920418 g/mol |
Monoisotopic Mass | 201.0920418 g/mol |
Topological Polar Surface Area | 20.2 Ų |
Heavy Atom Count | 13 |
Formal Charge | 0 |
Complexity | 145 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 2 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Edrophonium chloride is the chloride salt of edrophonium. A reversible inhibitor of cholinesterase with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes), it is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor, a diagnostic agent and an antidote. It is a quaternary ammonium salt and a chloride salt. It contains an edrophonium.