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105355-27-9

105355-27-9 structural image
Product Name: Pioglitazone
Formula: C19H20N2O3S
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CHEMICAL AND PHYSICAL PROPERTIES

Physical Description Solid
Color/Form Colorless needles from dimethylformamide and water
Melting Point 193-194C
Solubility Practically insoluble
LogP 2.3
Stability/Shelf Life Stable under recommended storage conditions. /Pioglitazone hydrochloride/
Decomposition Hazardous decomposition products formed under fire conditions: Carbon oxides, Nitrogen oxides (NOx), Sulfur oxides, Hydrogen chloride gas. /Pioglitazone hydrochloride/
Dissociation Constants 5.19
Other Experimental Properties White crystalline powder. Odorless. MW: 392.90 daltons. Soluble in N,N-dimethylformamide, slightly soluble in anhdydrous ethanol, very slightly soluble in acetone, acetonitrile, practically insoluble in water, insoluble in ether /Pioglitazone hydrochloride/

COMPUTED DESCRIPTORS

Molecular Weight 356.4 g/mol
XLogP3 3.8
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 7
Exact Mass 356.11946368 g/mol
Monoisotopic Mass 356.11946368 g/mol
Topological Polar Surface Area 93.6 Ų
Heavy Atom Count 25
Formal Charge 0
Complexity 466
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 1
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Pioglitazone is a member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity. It has a role as an insulin-sensitizing drug, an EC 2.7.1.33 (pantothenate kinase) inhibitor, a xenobiotic, an EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor, a ferroptosis inhibitor, a cardioprotective agent, a PPARgamma agonist, an antidepressant, a geroprotector and a hypoglycemic agent. It is a member of thiazolidinediones, an aromatic ether and a member of pyridines.