CHEMICAL AND PHYSICAL PROPERTIES
Physical Description | Solid |
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Color/Form | Colorless needles from dimethylformamide and water |
Melting Point | 193-194C |
Solubility | Practically insoluble |
LogP | 2.3 |
Stability/Shelf Life | Stable under recommended storage conditions. /Pioglitazone hydrochloride/ |
Decomposition | Hazardous decomposition products formed under fire conditions: Carbon oxides, Nitrogen oxides (NOx), Sulfur oxides, Hydrogen chloride gas. /Pioglitazone hydrochloride/ |
Dissociation Constants | 5.19 |
Other Experimental Properties | White crystalline powder. Odorless. MW: 392.90 daltons. Soluble in N,N-dimethylformamide, slightly soluble in anhdydrous ethanol, very slightly soluble in acetone, acetonitrile, practically insoluble in water, insoluble in ether /Pioglitazone hydrochloride/ |
COMPUTED DESCRIPTORS
Molecular Weight | 356.4 g/mol |
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XLogP3 | 3.8 |
Hydrogen Bond Donor Count | 1 |
Hydrogen Bond Acceptor Count | 5 |
Rotatable Bond Count | 7 |
Exact Mass | 356.11946368 g/mol |
Monoisotopic Mass | 356.11946368 g/mol |
Topological Polar Surface Area | 93.6 Ų |
Heavy Atom Count | 25 |
Formal Charge | 0 |
Complexity | 466 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 1 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Pioglitazone is a member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity. It has a role as an insulin-sensitizing drug, an EC 2.7.1.33 (pantothenate kinase) inhibitor, a xenobiotic, an EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor, a ferroptosis inhibitor, a cardioprotective agent, a PPARgamma agonist, an antidepressant, a geroprotector and a hypoglycemic agent. It is a member of thiazolidinediones, an aromatic ether and a member of pyridines.