Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

Homecas1051375-16-6

1051375-16-6

1051375-16-6 structural image
Product Name: GSK1349572
Formula: C20H19F2N3O5
Inquiry

CHEMICAL AND PHYSICAL PROPERTIES

Melting Point 190-193ºC
Solubility Slightly soluble
LogP 2.2
Dissociation Constants 8.2
Other Experimental Properties White to light yellow powder; slightly soluble in water /Dolutegravir sodium/

SAFETY INFORMATION

Signal word Warning
Pictogram(s)

Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

COMPUTED DESCRIPTORS

Molecular Weight 419.4 g/mol
XLogP3 2.4
Hydrogen Bond Donor Count 2
Hydrogen Bond Acceptor Count 8
Rotatable Bond Count 3
Exact Mass 419.12927704 g/mol
Monoisotopic Mass 419.12927704 g/mol
Topological Polar Surface Area 99.2 Ų
Heavy Atom Count 30
Formal Charge 0
Complexity 829
Isotope Atom Count 0
Defined Atom Stereocenter Count 2
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Dolutegravir is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (4R,12aS)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1. It has a role as a HIV-1 integrase inhibitor. It is a monocarboxylic acid amide, an organic heterotricyclic compound, a secondary carboxamide and a difluorobenzene. It is a conjugate acid of a dolutegravir(1-).

RELATED SUPPLIERS

Lupin Ltd

1Y
product:1051375-16-6 99%

Aurobindo Pharma Limited

1Y
product:Dolutegravir 98%

Macleods Pharmaceuticals Limited

1Y
product:Dolutegravir 1051375-16-6 98%

Anlon Healthcare Pvt Ltd

1Y
product:1051375-16-6 Dolutegravir 99%

HRV Global Life Sciences

1Y
product:1051375-16-6 99%

Venkatasai Life Sciences

1Y
product:Dolutegravir 99%

Solara Active Pharma Sciences Ltd

1Y
product:Dolutegravir 1051375-16-6 98%

Rivashaa Agrotech Biopharma Pvt. Ltd.

1Y
product:1051375-16-6 Dolutegravir 98%

Arene Lifesciences Limited

1Y
product:1051375-16-6 99%
All suppliers(13)