Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

Homecas1018899-04-1

1018899-04-1

1018899-04-1 structural image
Product Name: LX-4211
Formula: C21H25ClO5S
Inquiry

COMPUTED DESCRIPTORS

Molecular Weight 424.9 g/mol
XLogP3 3.2
Hydrogen Bond Donor Count 3
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 6
Exact Mass 424.1111228 g/mol
Monoisotopic Mass 424.1111228 g/mol
Topological Polar Surface Area 104 Ų
Heavy Atom Count 28
Formal Charge 0
Complexity 476
Isotope Atom Count 0
Defined Atom Stereocenter Count 5
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

PRODUCT INTRODUCTION

description

Sotagliflozin is a dual inhibitor of SGLT1 and SGLT2, the first of its kind, which is approved for use in the EU, in combination with insulin, to improve glycemic control in patients with type 1 diabetes mellitus (T1DM) and a BMI ≥27 kg/m2. Its potency in inhibiting SGLT2 is similar to that of other SGLT2 inhibitors, such as [canagliflozin] and [dapagliflozin], but its potency in inhibiting SGLT1 is >10-fold higher than its predecessors. The added inhibition of intestinal SGLT1 delays glucose absorption in the distal small intestine and colon, thereby reducing post-prandial glucose levels. Sotagliflozin was approved in the EU under the brand name "Zynquista" on April 26, 2019. A similar approval has also been sought in the US, but the FDA has since published a proposal to refuse the approval on the grounds that the data submitted did not show that it was safe under the proposed conditions of use.