Pramlintide

Product Specifications

Description:

Pramlintide acetate is an injectable human amylin analog that has been launched for the treatment of both type 1 and type 2 diabetes, in conjunction with insulin. While it is also a 37-amino acid peptide, it differs from its parent predecessor by the substitution of Ala-25, Ser-28, and Ser-29 with prolines. Not only do these modifications improve the solubility of the peptide, they also eliminate the aggregation observed with amylin, resulting in a stable synthetic analog with retention of biological activity that is suitable for pharmaceutical use. As an indication of potency, Pramlintide acetate inhibits the binding of radioiodinated rat amylin to rat nucleus accumbens membranes with a Ki value of 23 pM. Its mechanism of action mimics amylin; as a neurohormone that is cosecreted with insulin from the pancreatic β cells in response to meals, it is involved in glucose homeostasis. Both peptides lower postprandial glucose levels by inhibiting glucagon and by restraining the vagus-mediated rate of gastric emptying, thereby, slowing intestinal carbohydrate absorption. Furthermore, amylin, orPramlintide acetate, has the added benefit of inducing postprandial satiety resulting in weight loss in the patients with type 2 diabetes. Since Pramlintide acetate slows gastric emptying, it is contraindicated in patients with gastroparesis and in patients taking drugs that alter gastrointestinal motility (anticholinergic agents, such as, atropine) or slow down the intestinal absorption of nutrients (such as α-glucosidase inhibitors). Pramlintide acetate is also contraindicated in patients with hypoglycemic tendencies; due to co-administration with insulin, severe insulin-induced hypoglycemia is a risk. The most commonly reported adverse events include nausea, vomiting, anorexia, headache, abdominal pain, fatigue, dizziness, coughing, and pharyngitis.

Uses:

Pramlintide acetate is an analogue of human amylin used in the treatment of insulin dependent diabetes.

Company Profile

Wuhan wingroup Pharmaceutical Co.,Ltd located in Wuhan, Hubei Province, is a company dedicated to R&D,production and sales of chemical reagents, pharmaceutical intermediates, plantextracts and chemical raw materials. The company has a long-term cooperationwith Wuhan Research Institute and other universities. It is a pharmaceuticalenterprise oriented by the global pharmaceutical market demand and integratingthe research and development, industrialization and market operation ofinnovative drugs. At present, the company has submitted 10 domestic patents andone PCT patent (International Patent); And obtained the authorization of 7invention patents. The company has strong technical strength, advanced equipment,strict quality management system and high-quality after-sales service.

Over the years, our products have been widely sold to many countries and regions that we have established stable relations of cooperation with the traders and end users all around the world and have become a solid bridge among the suppliers, traders and end users.

Our Advantages

1. Quality control: We take quality as our life. We strictly control the quality of each process and establish a complete quality control system. We promise to bring 100% best quality products to consumers.

2. Trade capacity: We focus on chemical, biological medicine international trade for more than 10 years. Has the abundant product and the trade ability. Cooperative customers all over the world, good reputation.

3. transport capacity: We have professional freight agents, customs clearance agencies set up in the destination. Deliver your package safely. According to the customer's transport needs can choose: FEDEX UPS TNT DHL  air charter and sea.

4. Carefully packing: 1kg, 5kg, 15kg, 20kg, 25kg can be packed in different specifications. Packaging can be customized according to customer requirements. Aluminum foil bag and carton. Ensure the safety of transportation. And free samples are available.

5. Quality service: We have a professional customer service team and after sales team. Being proficient in each language will guarantee your after-sale service.

Certificate

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Packing&Shipping

1.Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);

2.Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).

3.Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg,NW: 1kg).

1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post andother couriers, weight from 10g to 1000kg or even bulker.

2. Shipping details & shipping documents will be provided andsent by email.

3.We keep tracking the shippment until clients well received.

4.After years export shipping experience, with professional and experienced cooperated forwarders,we ensure that goods can be  delivered in multiple ways safetly and efficiently.

FAQ

Q1:Can I get some samples?

A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2:Which kind of payment terms do you accept?

A: Payment by T/T, Western Union or Bitcoin.

Q3:Which transportation do we use?

A:Samples could be DHL, UPS, TNT, EMS, Fedex, and so on. For mass orders, it will be delivered by air or sea.

Q4:How about your delivery time?

Generally, it will take 3 to 5 days after receiving your advance payment.

Q5:How do you treat quality complaint?

A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.

Q6:How can we trust you?

A: You are always warm welcomed to visit us at any time.Before we start B2B, MIC has audited our company on-spot and approved our credit.

Q7:Do you test all your goods before delivery?

A:Yes, we have 100% test before delivery,International Authorized Third-Party Test for the products if you need are highly welcomed.