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Homecompany99% CAS 59-05-2 Methotrexate Powder High Purity
Methotrexate
Methotrexate
Methotrexate
Methotrexate
Methotrexate
Methotrexate

99% CAS 59-05-2 Methotrexate Powder High Purity

Price USD15.00
Packge 1kg
  • Min. Order:10kg
  • Supply Ability:20tons
  • Time:2022-06-28

Product Details

  • Product NameMethotrexate
  • CAS No.59-05-2
  • EINECS No.200-413-8
  • MFC20H22N8O5
  • MW454.45
  • InChIKeyFBOZXECLQNJBKD-VHLFKADZNA-N
  • AppearancepowderLight yellow to yellow
  • Water Solubility Insoluble. <0.1 g/100 mL at 19 ºC
  • storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
  • Melting point 195°C
  • Boiling point 561.26°C (rough estimate)
  • density 1.4080 (rough estimate)

Basic Info.

Grade
Pharmaceutcial Grade
CAS
59-05-2
Storage
Cool Dry Place
Deliver Time
5-10 Days
Appearance
Yellow Powder
Test Method
HPLC UV
Sample
Available
Shipping Method
Air(UPS, FedEx, TNT, EMS) or Sea
Mf
C20h22n8o5
Einecs No.
200-413-8
MW
454.44
Refractive Index
1.6910 (Estimate)
Density
1.4080 (Rough Estimate)
Transport Package
Bag or Drum
Specification
1kg/bag 25kg/drum
Origin
China
Production Capacity
10000kg/Months

Product Description

Product Description
NameMethotrexate
Synonyms(+)-Amethopterin; (+)-4-Amino-10-methylfolic acid; N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamic acid
Molecular FormulaC20H22N8O5
Molecular Weight454.44
CAS Registry Number59-05-2
EINECS200-413-8
Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate arrests the cell cycle in late G1/S-phase, therefore inhibiting the synthesis of DNA, RNA, thymidylates, and proteins. In the previous cases the inhibition of enzymes involved in purine metabolism, leading to accumulation of adenosine, or the suppression of intercellular adhesion molecule expression by T cells as the main mechanism of action by methotrexate. The compound has been observed to irreversibly inhibit dihydrofolate reductase (DHFR) and thymidylate synthetase (TS). Methotrexate has been shown to modulate inflammation by promoting adenosine release or inhibiting transmethylation reactions. In adherent splenic cells, IL-1 production was decreased by methorexate.

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Hebei Linwo New Material Technology Co., LTD

Hebei China
  • Since:2022-03-18
  • Address: Room 601, Unit 1, Building 1, 188 Xinhuali, North Xinhua Road, Xiangdu District, Xingtai city, Hebei
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