Metformin HCL
Price | USD120.00 |
Packge | 1kg |
- Min. Order:1kg
- Supply Ability:5000 Ton
- Time:2022-08-12
Product Details
- Product NameMetformin HCL
- CAS No.1115-70-4
- EINECS No.214-230-6
- MFC4H12ClN5
- MW165.62
- InChIKeyOETHQSJEHLVLGH-UHFFFAOYSA-N
- AppearancePowderWhite
- Melting point 223-226 °C(lit.)
- storage temp. 2-8°C
- Water Solubility Soluble in water (50 mg/ml), ethanol, and DMSO (50 mM).
- density 1.36[at 20℃]
Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces weight gain, hepatic lipid droplet content, and total cholesterol, LDL cholesterol, and triglyceride levels in the plasma of diet-induced obese mice when administered at doses of 10 or 50 mg/kg per day. It also reverses increased hepatic triglyceride and apolipoprotein A5 levels, as well as hepatic steatosis, in a dose-dependent manner in an ob/ob mouse model of non-alcoholic fatty liver disease (NAFLD). Metformin (250 mg/kg) reduces tumor growth in an HCT116 p53-\- human colon cancer mouse xenograft model, but has no effect on HCT116 p53-\- tumors overexpressing recombinant S. cerevisiae Ndi1 NADH dehydrogenase, a single-subunit ortholog of the multi-subunit mammalian mitochondrial complex I. Formulations containing metformin have been used in the treatment of type 2 diabetes.
Company Profile Introduction
Recommended supplier
-
VIP1年
- Gangwal Healthcare Pvt Ltd
- Metformin HCL IR Granules 1115-70-4 98%
- Inquiry
- 2024-04-27
-
VIP1年
- Granules India Limited
- 1115-70-4 99%
- Inquiry
- 2024-03-22
-
VIP1年
- Soros Molecules India
- Metformin hydrochloride 99%
- Inquiry
- 2024-03-16
-
VIP1年
- Turtle Pharma Private Limited
- 1115-70-4 98%
- Inquiry
- 2024-03-15
-
VIP1年
- Sohan Healthcare Pvt Ltd
- 1115-70-4 Metformin hydrochloride 99%
- Inquiry
- 2024-03-04
-
VIP1年
- Aarti Drugs Ltd (part of Aarti Group of Industries)
- Metformin hydrochloride 98%
- Inquiry
- 2024-03-01
-
VIP1年
- Exemed Pharmaceuticals (Oneiro Chemicals Pvt Ltd)
- 1115-70-4 98%
- Inquiry
- 2024-02-28
-
VIP1年
- Abhilasha Pharma Pvt Ltd
- 1115-70-4 Metformin hydrochloride 99%
- Inquiry
- 2024-02-21
-
VIP1年
- IOL Chemicals And Pharmaceuticals Limited
- Metformin hydrochloride 1115-70-4 98%
- Inquiry
- 2024-02-21
-
VIP1年
- Alfa Omega Pharma
- Metformin hydrochloride 98%
- Inquiry
- 2024-02-17
- Since:2020-09-17
- Address: Room 902, Unit 2, Building 8, Haolin Garden,Shangcheng,No. 69 Shangcheng Road, Xinhua District, Shij