Cilomilast
| Price | USD1.00 |
| Packge | 1g |
- Min. Order:1g
- Supply Ability:1ton
- Time:2020-01-13
Product Details
- Product NameCilomilast
- CAS No.153259-65-5
- EINECS No.200-258-5
- MFC20H25NO4
- MW343.42
- Appearancepowderwhite to beige
- Melting point 157°C
- storage temp. -20°C
- Boiling point 549.1±50.0 °C(Predicted)
- density 1.21±0.1 g/cm3(Predicted)
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Common Name
Density
1.2±0.1 g/cm3
Boiling Point
549.1±50.0 °C at 760 mmHg
Molecular Formula
C20H25NO4
Melting Point
157ºC
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Use of Cilomilast
Cilomilast(SB 207499; Ariflo) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity.IC50 value: 110 nMTarget: PDE 4Cilomilast (SB-207499) inhibits HPDE4 and LPDE4 catalytic activity with equal potency (Ki ≈100 nM). SB-207499 and rolipram are equipotent against LPDE4, but Cilomilast (Ariflo, SB-207499) is 100-fold less potent against HPDE4. This profile suggests that Cilomilast (Ariflo, SB-207499) retain the anti-inflammatory activity of rolipram yet have a decreased tendency to produce side effects.
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Name
4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylic acid
Synonym
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Description
Cilomilast(SB 207499; Ariflo) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity.IC50 value: 110 nMTarget: PDE 4Cilomilast (SB-207499) inhibits HPDE4 and LPDE4 catalytic activity with equal potency (Ki ≈100 nM). SB-207499 and rolipram are equipotent against LPDE4, but Cilomilast (Ariflo, SB-207499) is 100-fold less potent against HPDE4. This profile suggests that Cilomilast (Ariflo, SB-207499) retain the anti-inflammatory activity of rolipram yet have a decreased tendency to produce side effects.
Related Catalog
References
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Density
1.2±0.1 g/cm3
Boiling Point
549.1±50.0 °C at 760 mmHg
Melting Point
157ºC
Molecular Formula
C20H25NO4
Molecular Weight
343.417
Flash Point
285.9±30.1 °C
Exact Mass
343.178345
PSA
79.55000
LogP
3.30
Vapour Pressure
0.0±1.6 mmHg at 25°C
Index of Refraction
1.568
Storage condition
?20°C
Water Solubility
DMSO: soluble15mg/mL, clear
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SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifiers
Product name: Cilomilast
REACH No.: A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later
registration deadline.
CAS-No.: 153259-65-5
Relevant identified uses of the substance or mixture and uses advised against
Identified uses: Laboratory chemicals, Manufacture of substances
SECTION 2: Hazards identification
Classification of the substance or mixture
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Label elements
This substance is not classified as dangerous according to Directive 67/548/EEC.
Other hazards - none
SECTION 3: Composition/information on ingredients
CAS-No.: 153259-65-5
Relevant identified uses of the substance or mixture and uses advised against
Identified uses: Laboratory chemicals, Manufacture of substances
SECTION 2: Hazards identification
Classification of the substance or mixture
Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.
This substance is not classified as dangerous according to Directive 67/548/EEC.
Label elements
This substance is not classified as dangerous according to Directive 67/548/EEC.
Other hazards - none
SECTION 3: Composition/information on ingredients
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
- Since:2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
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