AST 487
| Price | USD1.00 |
| Packge | 1KG |
- Min. Order:1KG
- Supply Ability:1ton
- Time:2020-01-03
Product Details
- Product NameAST 487
- CAS No.630124-46-8
- EINECS No.205-525-8
- MFC26H30F3N7O2
- MW529.56
- AppearanceSolidWhite to Light Yellow
- Boiling point 563.1±50.0 °C(Predicted)
- density 1.341±0.06 g/cm3(Predicted)
- storage temp. under inert gas (nitrogen or Argon) at 2-8°C
- Melting point 162-164°C
▼
▲
AST 487 Basic information
▼
▲
Product Name:
Synonyms:
AST 487;NVP-AST 487;1-{4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl}-3-(4-{[6-(methylamino)-4-pyrimidinyl]oxy}phenyl)urea;1-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-((6-(methylamino)pyrimidin-4-yl)oxy)phenyl)urea
CAS:
MF:
C26H30F3N7O2
MW:
529.5573096
EINECS:
Product Categories:
Mol File:
▼
▲
AST 487 Chemical Properties
▼
▲
Boiling point
563.1±50.0 °C(Predicted)
density
1.341±0.06 g/cm3(Predicted)
pka
13.33±0.70(Predicted)
▼
▲
Safety Information
▼
▲
▼
▲
AST 487 Usage And Synthesis
▼
▲
Uses
AST-487 is an inhibitor of RET (IC50 = 0.88 μM), FLT3 (Ki = 0.52 μM), KDR (IC50 = 0.17 μM), c-Abl (IC50 = 0.02 μM), and c-Kit (IC50 = 0.5 μM). It has been shown to inhibit RET autophosphorylation and activation of downstream effectors and to prevent the growth of human thyroid cancer cell lines with activating mutations of RET but not of lines without RET mutations. In xenografts of NIH3T3 cells expressing oncogenic RET and of the MTC cell line TT in nude mice, AST-487 dose dependently inhibited tumor growth. It also demonstrates antiproliferative effects on primary cells from acute myelocytic leukemia patients and on cell lines expressing FLT3-ITD or FLT3 kinase domain point mutants.[Cayman Chemical]
▼
▲
AST 487 Preparation Products And Raw mate
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
Recommended supplier
-
VIP2年
- chromosynth pvt ltd
- 487-26-3 98%
- Inquiry
- 2023-08-05
-
VIP2年
- PEE ESS AROMATICS
- 487-26-3 Flavanone(2,3-Dihydroflavone) 98%
- Inquiry
- 2023-07-03
- Since:2014-12-17
- Address: Room 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H
INQUIRY