Tacedinaline
| Price | USD5.00 |
| Packge | 5KG |
- Min. Order:1KG
- Supply Ability:1ton
- Time:2019-09-04
Product Details
- Product NameTacedinaline
- CAS No.112522-64-2
- EINECS No.200-256-5
- MFC15H15N3O2
- MW269.3
- Appearancepowderoff-white
- storage temp. Keep in dark place,Inert atmosphere,2-8°C
- Melting point 216.1 °C
- Boiling point 450.6±30.0 °C(Predicted)
- density 1.322±0.06 g/cm3(Predicted)
▼
▲
Tacedinaline Basic information
▼
▲
Product Name:
Synonyms:
Benzamide, 4-(acetylamino)-N-(2-aminophenyl)-;acetyldinaline;Tacedinaline;CI 994;N-Acetyldinaline;4-AcetaMido-N-(2-aMinophenyl)benzaMide;4-Acetylamino-N-(2'-aminophenyl)benzamide;Cl-994(Tacedinalin,N-Acetyldinalin)
CAS:
MF:
C15H15N3O2
MW:
269.3
EINECS:
Product Categories:
Mol File:
▼
▲
Tacedinaline Chemical Properties
▼
▲
RTECS
CU8702023
storage temp.
Store at +4°C
solubility
Soluble in DMSO
form
powder
color
off-white
Sensitive
Air Sensitive
▼
▲
Tacedinaline Usage And Synthesis
▼
▲
Uses
Tacedinaline is a histone deacetylase (HDAC) inhibitor. Tacedinaline is an anti-cancer agent as HDAC inhibitors block angiogenesis, arrest cell growth, and lead to differentiation and apoptosis in tum or cells. Studies show Tacedinaline to be effective against acute myeloid leukemia in vitro and in vivo when used in combination with conventional anti-cancer agents.
Definition
ChEBI: A benzamide obtained by formal condensation of the carboxy group of 4-acetamidobenzoic acid with one of the amino groups of 1,2-phenylenediamine. An oral cytostatic drug with impressive differential activity against leukemic cells and normal stem-cells. Al o used in combination therapy for selected tumors including non-smoll cell lung, pancreatic, breast, and colorectal cancers.
Biological Activity
Orally active histone deacetylase (HDAC) inhibitor (K i values are 0.41, 0.75, >100 and >100 μ M for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Mediates G 1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo .
▼
▲
Tacedinaline Preparation Products And Raw materials
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
INQUIRY