SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE
| Price | USD1.00 | USD2.00 |
| Packge | 1KG | 1KG |
- Min. Order:1KG
- Supply Ability:200kg
- Time:2019-09-02
Product Details
- Product NameSIBUTRAMINE HYDROCHLORIDE MONOHYDRATE
- CAS No.125494-59-9
- EINECS No.603-075-3
- MFC17H29Cl2NO
- MW334.32
- Appearancesolidwhite
- Melting point 193-195.5°C
- storage temp. Room temp
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Product Name:
Synonyms:
1-(4-Chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)cyclobutanemethanamine hydrochloride;[1-[1-(4-chlorophenyl)cyclobutyl]-3-methyl-butyl]-dimethyl-amine hydrate hydrochloride;1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethyl-butan-1-amine hydrate hydrochloride;1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine hydrate hydrochloride;1-(4-Chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)cyclobutanemethanamine hydrochloride monohydrate;Sibutramine Hydrochloride CIV (125 mg);SIBUTRAMINE HCL HYDRATE;SIBUTRAMINE HCL MONOHYDRATE
CAS:
MF:
C17H29Cl2NO
MW:
334.32
EINECS:
603-075-3
Product Categories:
Mol File:
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SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE Chemical Properties
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Melting point
193-195.5°C
Fp
9℃
storage temp.
Room temp
solubility
DMSO: >30mg/mL
form
solid
color
white
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Safety Information
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Hazard Codes
Risk Statements
Safety Statements
RIDADR
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany
3
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SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE Usage And Synthesis
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Description
Sibutramine was introduced as Meridia in the US for the control of obesity, in conjunction with a reduced-calorie diet. Sibutramine can be prepared in four steps from 4-chlorobenzyl cyanide. Sibutramine acts as a serotonin and noradrenaline reuptake inhibitor ; in animal studies, it reduces energy intake by creating a satieted feeling and increases energy expenditure by enhancing thermogenesis. In a clinical study in obese patients treated with 10 or 15 mg of Sibutramine once-daily, meaningful weight loss was sustained for 12 months ; an additional study demonstrated a lack of abuse potential. An appreciable part of Sibutramine's effect would also be due to its 2N-mono and didesmethylmetabolites, which are very potent monoamine reuptake inhibitors themselves.
Chemical Properties
White Solid
Originator
Knoll (Germany)
Uses
A serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure
Uses
antiobesity agent;neurotransmitter reuptake inhibitor
Uses
antihyperlipidemic
Brand name
Meridia (Abbott);Meridia, Reductil.
Biological Activity
Anti-obesity agent. Prevents resorption of the messenger substances serotonin and noradrenalin in the brain, allowing them to act at higher concentration on nerve cells and increasing the feeling of satiety.
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SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE Preparation Products And Raw materials
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
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- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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