Cefapirin sodium

Cefapirin sodium Basic information

Product Name:

Synonyms:

2,0)oct-2-ene-2-carboxylicacid,3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo(;7-(2-(4-pyridylthio)acetamido)-,acetate(ester),monosodiumsalt;blp1322;CEFADYL;CEPHAPIRIN;CEPHAPIRIN BENZATHINE;CEPHAPIRIN SODIUM;CEPHAPIRIN SODIUM SALT

CAS:

MF:

C17H16N3O6S2.Na

MW:

445.45

EINECS:

246-194-2

Product Categories:

-;CEFADYL

Mol File:

 

Cefapirin sodium Chemical Properties

alpha 

+152～+170゜(25℃/D)(c=2,H2O)(calculated on the dehydrous basis)

storage temp. 

0-6°C

solubility 

Soluble in water, practically insoluble in methylene chloride.

form 

powder

pka

pKa 2.15 (Uncertain)

InChIKey

VGEOUKPOQQEQSX-OALZAMAHSA-M

CAS DataBase Reference

 

Safety Information

Hazard Codes 

Risk Statements 

Safety Statements 

RTECS 

XI0382000

HS Code 

2941906000

MSDS Information

 

Cefapirin sodium Usage And Synthesis

Chemical Properties

White or pale yellow powder.

Uses

Cephalosporin antibacterial.

Definition

ChEBI: The sodium salt of cephapirin. A first-generation cephalosporin antibiotic, it is effective against gram-negative and gram-positive organisms. Being more resistant to beta-lactamases than penicillins, it is effective agains most staphyloco ci, though not methicillin-resistant staphylococci.

Brand name

Cefadyl (Apothecon).

Clinical Use

Cephapirin (Cefadyl) is a semisynthetic 7-ACA derivativereleased in the United States in 1974. It closely resemblescephalothin in chemical and pharmacokinetic properties. Likecephalothin, cephapirin is unstable in acid and must beadministered parenterally in the form of an aqueous solutionof the sodium salt. It is moderately protein bound (45%–50%)in plasma and cleared rapidly by the kidneys. Cephapirin andcephalothin are very similar in antimicrobial spectrum andpotency. Conflicting reports concerning the relative occurrenceof pain at the site of injection and thrombophlebitis afterintravenous injection of cephapirin and cephalothin are difficultto assess on the basis of available clinical data.