BAY-57-1293
| Price | USD7.00 |
| Packge | 1KG |
- Min. Order:1KG
- Supply Ability:100KG
- Time:2019-07-10
Product Details
- Product NameBAY-57-1293
- CAS No.348086-71-5
- MFC18H18N4O3S2
- MW402.49
- AppearancesolidWhite to off-white
- Boiling point 639.4±65.0 °C(Predicted)
- density 1.396±0.06 g/cm3(Predicted)
- storage temp. 2-8°C(protect from light)
JD 607 100
| Product Name: | BAY-57-1293 |
| Synonyms: | BAY-57-1293;Pritelivir;N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide;Pritelivir,BAY-57-1293;Benzeneacetamide, N-[5-(aminosulfonyl)-4-methyl-2-thiazolyl]-N-methyl-4-(2-pyridinyl)-;AIC316;N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide BAY57-1293 Pritelivir;2-METHYL-2-PROPANYL [4-(CHLOROSULFONYL)PHENYL]CARBAMATE |
| CAS: | 348086-71-5 |
| MF: | C18H18N4O3S2 |
| MW: | 402.49052 |
| EINECS: | |
| Product Categories: | Inhibitors |
| Mol File: | 348086-71-5.mol |
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| BAY-57-1293 Chemical Properties |
| Safety Information |
| BAY-57-1293 Usage And Synthesis |
| Enzyme inhibitor | This antiviral (FW = 402.49 g/mol; CAS 348086-71-5), also named BAY 57-1293 and N-methyl-N-(4-methyl-5-sulfamoyl-1,3-thiazol-2-yl)-2-[4- (pyridin-2-yl)phenyl]acetamide, inhibits replication of herpes simplex virus (HSV) types 1 and 2 by blocking the enzymatic activity of the viral primase-helicase complex (IC50 ≈ 20 nM)). Although pritelivir is highly active against HSV-1 and superior to acyclovir in Vero cells, drug resistance has been detected in two different strains of HSV at 10-4 to 10-5, and resistant variants are present, even before the selection was applied. Resistant variants did not readily revert to a drug-sensitive phenotype in the absence of the inhibitor, and representative pritelivir-resistant variants were cross-resistant to BILS-22-BS, another helicase-primase inhibitor (HPI). Notably, variants resistant to BAY 57-1293 retained sensitivity to the nucleoside analogue, ACV. Two HSV-1 mutants, that are 100x and >3000x resistant to ritelivir, have substitutions in the UL5 helicase protein (e.g., one with A4V and K356Q mutations, and the other with a single G352R mutation). Marker transfer experiments confirmed that K356Q and G352R (near the predicted functional domain of HSV-1 helicase)) are the drug-resistance mutations that are directly associated with differences in virus growth in tissue culture. Moreover, to achieve maximum potency, pritelivir interacts with both components (UL5 and UL52) of the helicaseprimase complex, but BILS-22-BS does not. Herpes simplex type 1 (HSV1) infected cells form β-amyloid (Aβ) and abnormally phosphorylated Tau (P-Tau) in vitro, and pritelivir is more effective that acyclovir in preventing these Alzheimer-associated proteins. |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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