Raloxifene
| Price | USD3.00 |
| Packge | 3ASSAYS |
- Min. Order:1KG
- Supply Ability:100kg
- Time:2019-07-10
Product Details
- Product NameRaloxifene
- CAS No.249296-44-4
- MFC13H13N3
- MW211.26
- AppearancePowderLight yellow to yellow
- Melting point 138.5 °C
- Boiling point 400.6±40.0 °C(Predicted)
- density 1.247±0.06 g/cm3(Predicted)
- storage temp. Store at -20°C
| Varenicline Basic information |
| Product Name: | Varenicline |
| Synonyms: | Varenicline Impurity;VARENICLINE;7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine;Vareniclene;6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro-;Varenicline free base;Chantix;Cp 526555 |
| CAS: | 249296-44-4 |
| MF: | C13H13N3 |
| MW: | 211.26 |
| EINECS: | |
| Product Categories: | API intermediates;API |
| Mol File: | 249296-44-4.mol |
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| Varenicline Chemical Properties |
| Safety Information |
| Hazardous Substances Data | 249296-44-4(Hazardous Substances Data) |
| Varenicline Usage And Synthesis |
| Description | Varenicline, a partial agonist of the a4b2 nicotinic receptor, is a first-in-class drug launched by Pfizer as an aid to smoking cessation treatment. Varenicline exhibits dual action by decreasing craving and withdrawal symptoms, and by decreasing the reinforcement associated with smoking. The addictive properties of nicotine are thought to be mediated in part through its action as an agonist at α4β2 neuronal nicotinic acetylcholine receptors (nAChRs). Activation of α4β2 receptors by nicotine increases the release of dopamine in the mesolimbic system, an effect that is shared by most drugs of abuse. As nicotine levels decrease, dopamine levels decline, which in turn stimulates the urge to smoke. Additionally, a reduced dopaminergic tone due to abstinence from smoking stimulates craving and the withdrawal syndrome. A partial agonist of α4β2 receptors such as varenicline is expected to elicit a moderate and sustained increase in dopamine levels to relieve craving and withdrawal symptoms. In addition, by competitively binding to a4b2 receptors and inhibiting nicotineinduced dopaminergic activation, a partial agonist could attenuate the pharmacologic reward associated with smoking. |
| Originator | Pfizer (US) |
| Uses | Smoking cessation (selective nicotinic receptor modulator). |
| Definition | ChEBI: An organic heterotetracyclic compound that acts as a partial agonist for nicotinic cholinergic receptors and is used (in the form of its tartate salt) as an aid to giving up smoking. |
| Brand name | Chantix (Pfizer). |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
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- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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