2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3
| Price | USD1.00 |
| Packge | 1KG |
- Min. Order:1KG
- Supply Ability:Customized
- Time:2019-07-06
Product Details
- Product Name2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3
- CAS No.104121-92-8
- EINECS No.686-849-3
- MFC30H50O5
- MW490.71
- AppearancePowderWhite to off-white
- density 1.10
- Melting point 126-128℃
- Boiling point 655.7±55.0 °C(Predicted)
- storage temp. Store at -20°C
SP752
| 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 Basic information |
| Product Name: | 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 |
| Synonyms: | 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3;Eldecalcitol;ED-71;Eldecalcitol(ED-71);2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitaMin D3;(1R,Z)-5-((E)-2-((1R,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-2-(3-hydroxypropoxy)-4-methylenecyclohexane-1,3-diol;1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 |
| CAS: | 104121-92-8 |
| MF: | C30H50O5 |
| MW: | 0 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 104121-92-8.mol |
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| 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 Chemical Properties |
| Melting point | 126-128℃ |
| density | 1.10 |
| Safety Information |
| 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 Usage And Synthesis |
| Description | Eldecalcitol (Edirol) was approved in January 2011 by the Japanese Ministry of Health, Labor, and Welfare for the treatment of osteoporosis. Because of vitamin D’s central role in the bone health, vitamin D and analogs of vitamin D have been used to treat patients diagnosed with osteoporosis. Eldecalcitol is an analog of the active form of vitamin D, calcitriol, in which the lower cyclohexane ring contains a hydroxypropyl group. The synthesis of eldecalcitol involves the assembly of two units, a fully protected (3S,4S,5R)-oct-1-en-7-yne-3,4,5-triol and a fused bicyclic system, (R)-6- ((1R,3aR,7aR,E)-4-(bromomethylene)-7a-methyloctahydro-1H-inden-1- yl)-2-methylheptan-2-ol, through a Diels-Alder reaction to give fully protected eldecalcitol. The hydroxyl groups are then deprotected to give the parent molecule. Eldecalcitol binds to the vitaminDreceptor 2.7-fold more potently than calcitriol, while only weakly inhibiting serum parathyroid hormone. |
| Originator | Chugai Pharmaceutical/Roche (Japan) |
| Definition | ChEBI: A hydroxycalciol that is calcitriol with a 3-hydroxypropoxy group at position 2 |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
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- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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