METHYL 4-AMINOSALICYLATE

Price	USD1.00
Packge	1KG

Product Details

Product NameMETHYL 4-AMINOSALICYLATE
CAS No.4136-97-4
EINECS No.223-958-3
MFC8H9NO3
MW167.16
AppearancePowderWhite to Pale Beige
Melting point 120-123°C
density 1.305±0.06 g/cm3 (20 ºC 760 Torr)
Water Solubility Slightly soluble in water.
Boiling point 120 °C
storage temp. Keep in dark place,Inert atmosphere,Room temperature

SP476

METHYL 4-AMINOSALICYLATE Basic information

Product Name:	METHYL 4-AMINOSALICYLATE
Synonyms:	Methyl 4-aminosalicylate, 3-Hydroxy-4-(methoxycarbonyl)aniline, 5-Amino-2-(methoxycarbonyl)phenol;Methyl 4-amino-2-hydroxybenzoate 97%;Benzoic acid,4-aMino-2-hydroxy-, Methyl ester;Methyl 4-aMino-2-hydroxybenzenecarboxylate, >95%;4-AMINOSALICYLATE;METHYL 4-AMINO-2-HYDROXYBENZOATE;P-AMINO METHYL SALICYLATE;4-amino-2-hydroxy-benzoicacimethylester
CAS:	4136-97-4
MF:	C8H9NO3
MW:	167.16
EINECS:	223-958-3
Product Categories:	-
Mol File:	4136-97-4.mol

METHYL 4-AMINOSALICYLATE Chemical Properties

Melting point	120-123°C
density	1.305±0.06 g/cm3 (20 ºC 760 Torr)
form	Powder
Water Solubility	Slightly soluble in water.
λmax	254nm(lit.)
CAS DataBase Reference	4136-97-4(CAS DataBase Reference)

Safety Information

RTECS	VO1683000
HazardClass	IRRITANT

MSDS Information

METHYL 4-AMINOSALICYLATE Usage And Synthesis

Enzyme inhibitor

This aromatic acid (FWfree-acid = 153.14 g/mol: CAS 2066-89-9; Abbreviation: PAS), also known by the trade name Paser? as well as 4- aminosalicylic acid or p-aminosalicylic acid, is an analogue of p- aminobenzoate, an essential intermediate in the bacterial folate synthesis. PAS potently inhibits the growth of Mycobacterium bovi, M. smegmatis, and M. tuberculosis. It is also used for the treatment of such inflammatory bowel diseases as ulcerative colitis and Crohn's disease, most likely by inhibiting NF-kB. Primary Mode of Antimicrobial Action: Although in use clinically for over 60 years, p-aminosalicylate’s inhibitory mechanism had proved elusive. Recent studies, however, demonstrated that PAS is prodrug, one that targets dihydrofolate reductase, or DHFR. PAS is first converted by dihydropteroate synthase (DHPS) a nd dihydrofolate synthase (DHFS) to a hydroxyl-dihydrofolate antimetabolite, which in turn inhibits DHFR. PAS is about as efficient a DHPS substrate as its natural substrate pABA, and inhibition of DHPS or mutation in DHFS prevents the formation of the antimetabolite and confers resistance to PAS.

METHYL 4-AMINOSALICYLATE Preparation Products And Raw materials

Preparation Products

Methyl 4-acetamido-2-methoxybenzoate-->4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide-->METHYL 4-ACETAMIDO-2-METHOXYBENZOAT

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.

Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.

Recommended supplier

VIP1年
Meck Pharmaceuticals and Chemicals Pvt. Ltd.
Sodium p-aminosalicylate dihydrate 6018-19-5 98%
Inquiry
2024-01-09

Product Details

Company Profile Introduction

Recommended supplier

career henan chemical co