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Diclofenac sodium
Diclofenac sodium

Diclofenac sodium

Price USD10.00
Packge 1KG
  • Min. Order:1KG
  • Supply Ability:500tons/month
  • Time:2022-08-04

Product Details

  • Product NameDiclofenac sodium
  • CAS No.15307-79-6
  • EINECS No.239-346-4
  • MFC14H10Cl2NNaO2
  • MW318.13
  • InChIKeyKPHWPUGNDIVLNH-UHFFFAOYSA-M
  • AppearanceWhite solidWhite to Almost white
  • Melting point 288-290°C
  • storage temp. room temp
  • Water Solubility Soluble in water to 50mg/ml.
  • density 0.781 g/cm3

Diclofenac sodium supplier

whatsapp/ signal:

+8613292890173
luna@speedgainpharma.com


Diclofenac Sodium is the salt form of diclofenac, an active metabolite of the NSAID aceclofenac (sc-217557). Hydrolysis of aceclofenac, an inhibitor of interleukin-1B-induced prostaglandin E2 production with no inhibitory activity against Cox (cyclooxygenase), generates diclofenac, an inhibitor of both Cox-1 and Cox-2. Oxidation of diclofenac produces the metabolite  4'-hydroxy diclofenac (sc-202423) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy  diclofenac suppresses prostaglandin E2 synthesis, producing antiinflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble

amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9.

 

Specification of Diclofenac Sodium

 

Characteristics

 

White crystalline powder

 Solubility:

 

Sparingly soluble in water, freely soluble in methanol, ethanol(96%);slightly soluble in acetone; practically insoluble in ether.,

Melting point

275-277

Related Substances:

Single impurity max 0.2%

total impurity max 0.5%

Heavy metal:

 

Max 10ppm

Loss on drying

 

Max 0.5%

Assay:

99.0-101.0%


Company Profile Introduction

Shanxi NAIPU Import &?export Co.,ltd. dedicated to the development, production and marketing of chemicals which is specialized in Cosmetic Raw Materials (BTMS, Candelilla wax) ,?Water Treatment Chemicals ,?such as Isocyanuric acid series (SDIC,,ICA ), Daily Chemicals, Detergent &?Disinfectant Raw Materials... With business concept of Honest &?Creditable business, Harmonious development! NAIPU has been insisting on the scientific management method and positive sales measures, and has developed the vigorous development pattern. To adapt the rapid development, Develop established R?& D?Dept, Purchase Dept. and Sales Dept. composed of several specialists to offer pre-sales, after-sales service for different customers and products. With powerful product design, development and material purchase, good experience at production and product distribution, NAIPU will become stronger and stronger along with the market. Clients' satisfaction is our principle. Good reputation is our origin! Let us reach a?brilliant new achievement hand-in-hand.

  • Since:2021-06-22
  • Address: Shijiazhuang City Hebei Province
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