Chelerythrine chloride
| Price | USD1.00 | USD1.00 |
| Packge | 1KG | 1KG |
- Min. Order:1 mg
- Supply Ability:100KG
- Time:2019-07-06
Product Details
- Product NameChelerythrine chloride
- CAS No.34316-15-9
- EINECS No.251-930-0
- MFC21H18NO4+
- MW348.37192
- AppearanceSolidLight Yellow to Dark Orange
- Melting point 195-205°C
- storage temp. Desiccate at -20°C
- Boiling point 496.37°C (rough estimate)
- density 1.2985 (rough estimate)
| Chelerythrine chloride Basic information |
| Product Name: | Chelerythrine chloride |
| Synonyms: | CHELERYTHRINE(TODDALINE)(RG);1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridinium;1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride;Chelerythrine chloride;1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;2,3-(Epoxymethanoxy)-5-methyl-7,8-dimethoxybenzo[c]phenanthridine-5-ium;Cheleritrine;3895-92-9 (Chloride) |
| CAS: | 34316-15-9 |
| MF: | C21H18NO4+ |
| MW: | 348.37192 |
| EINECS: | 251-930-0 |
| Product Categories: | Natural Plant Extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
| Mol File: | 34316-15-9.mol |
 |
|
| Chelerythrine chloride Chemical Properties |
| Melting point | 195-205°C |
| Boiling point | 496.37°C (rough estimate) |
| density | 1.2985 (rough estimate) |
| refractive index | 1.5614 (estimate) |
| storage temp. | Desiccate at -20°C |
| CAS DataBase Reference | 34316-15-9(CAS DataBase Reference) |
| Chelerythrine chloride Usage And Synthesis |
| Description | Chelerythrine chloride is the chloride form of Chelerythrine chloride which is a benzophenanthridine alkaloid isolated from the plant Chelidonium majus (greater celandine). It is a kind of potent, selective, and cell-permeable protein kinase C inhibitor, an efficient antagonist of G-protein-coupled CB1 receptors, and an independent activator of MAPK pathways. It has a wide range of biological activities including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. It has reported of that it is capable of inducing apoptosis in HL-60 human promyelocytic leukemia cells and several other cancer cell lines. The underlying mechanism is through its effects of inhibiting the binding of BclXL to Bax or Bad. |
| References | https://en.wikipedia.org/wiki/Chelerythrine https://www.scbt.com/scbt/product/chelerythrine-chloride-3895-92-9 https://www.tocris.com/dispprod.php?ItemId=2342#.WQmZVVNsgZQ |
| Definition | ChEBI: A benzophenanthridine alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae. |
| Biological Activity | Potent, cell-permeable inhibitor of protein kinase C (IC 50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL to Bak (IC 50 = 1.5 μ M) or Bad proteins and stimulates apoptosis. |
| Purification Methods | Chelerythrine crystallises from CHCl3 on addition of MeOH [Manske Can J Res 21B 140 1943, UV: Hruban et al. Coll Czech Chem Commun 35 3420 1970]. The pseudo base is colourless while the salts are yellow in aqueous solution and are fluorescent. |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
INQUIRY