Flumequine
| Price | USD1.00 |
| Packge | 1kg |
- Min. Order:1g
- Supply Ability:100KG
- Time:2019-07-06
Product Details
- Product Name Flumequine
- CAS No.42835-25-6
- EINECS No.255-962-6
- MFC14H12FNO3
- MW261.25
- Appearancepowderwhite to off-white
- storage temp. Sealed in dry,Store in freezer, under -20°C
- Melting point 253-255°C
- Water Solubility Soluble in DMSO and dilute alkali hydroxides. Insoluble in water
- Boiling point 439.7±45.0 °C(Predicted)
- density 1.45±0.1 g/cm3(Predicted)
| Flumequine Basic information |
| Product Name: | Flumequine |
| Synonyms: | 9-Fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid;FLUMEQUIN;FLUMEQUINE;Fluoromethylquinoline;Flumequine solution;FLUMEQUINE STANDARD SOLUTION;FLUMEQUINE PESTANAL, 250 MG;Fluoromethyl |
| CAS: | 42835-25-6 |
| MF: | C14H12FNO3 |
| MW: | 261.25 |
| EINECS: | 255-962-6 |
| Product Categories: | Aromatics Compounds;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Quinolones and Fluoroquinolones;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics A-FAntibiotics;Chemical Structure Class;Inhibits an EnzymeAntibiotics;Interferes with DNA SynthesisAntibiotics;Mechanism of Action;Spectrum of Activity;API's;Pharmaceutical raw material;FLUGERAL |
| Mol File: | 42835-25-6.mol |
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| Flumequine Chemical Properties |
| Melting point | 253-255°C |
| RTECS | DK1672000 |
| Fp | >110°(230°F) |
| storage temp. | 0-6°C |
| solubility | 1 M NH4OH: soluble50mg/mL |
| pka | pKa 6.42(H2O t=25.0 I=0.025)(Approximate) |
| color | white to off-white |
| Water Solubility | Soluble in DMSO and dilute alkali hydroxides. Insoluble in water |
| Merck | 14,4137 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 42835-25-6(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-36/37/39-27-26 |
| WGK Germany | 3 |
| F | 10 |
| HS Code | 29339900 |
| Hazardous Substances Data | 42835-25-6(Hazardous Substances Data) |
| MSDS Information |
| Provider | Language |
|---|---|
| 9-Fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid | English |
| SigmaAldrich | English |
| Flumequine Usage And Synthesis |
| Animal-specific antibacterial drugs | It appears as white powder and is odorless and tasteless. It is insoluble in water but is immiscible with organic solvent. Flumequine is a kind of synthetic second-generation, animal-specific quinolone antibacterial drugs. It is currently the only non-humans shared broad-spectrum antimicrobial veterinary drug. It is taken as the substitute product of norfloxacin. It has a strong bactericidal activity with excellent efficacy in the treatment of animal bacterial diseases. Its main effect is to inhibit bacterial deoxy nucleic acid (DNA) gyrase, interfering with the deoxyribonucleic acid (DNA) synthesis, thereby causing failure of cell for further division, and thus playing the role of killing bacteria. It is mainly used in animal bacterial respiratory disease including E. coli, dysentery, salmonellosis, typhoid, fowl cholera, staphylococcal disease and infectious rhinitis. It can also be used for the treatment of E. coli disease, monospora disease and Vibrio disease in aquatic animals with strong inhibitory effect on the Aeromonas hydrophila. Flumequine was first successfully developed by the Rinker laboratory and had been successively and widely used in the EU and Japan and other countries in livestock and aquaculture since 1970s with excellent efficacy in the treatment of various kinds of diseases caused by Gram-negative infections, especially for the treatment of livestock, poultry and aquatic animal diseases caused by Escherichia coli, mycoplasma, and Aeromonas hydrophila. It had been gradually developed and approved to enter into market by our country in the late 1990s and mainly used for the control of bacterial infection diseases of salmon, trout, shrimp, eel and pigs as well as chickens. Since quinolones-class sodium flumequine can inhibit bacterial DNA gyrase and has a broad spectrum antibiotic, high efficiency, low toxicity and strong tissue penetration capability with no anesthesia effect, it has become one of the most important anti-infective drugs in veterinary clinical diagnosis and aquaculture and has been used extensively for the treatment, prevention and promoting growth. Because of its resistance and potential carcinogenicity, the European Union, Japan and China have all provided their maximal residue limit in the tissue (our country and the European Union both use the value of 100ppb). The current methods of detecting flumequine mainly include fluorescent spectrophotometry, enzyme-linked assay (ELISA) and liquid chromatography. ELISA, with its high sensitivity and easy operation, has become routine screening methods. This information is edited by Xiongfeng Dai from Chemicalbook. |
| Uses | It is a kind of newly synthetic broad-spectrum antimicrobial drugs with excellent efficacy in the treatment of animal bacterial diseases. It can be used as pharmaceutical raw material. |
| Chemical Properties | White Crystalline Solid |
| Uses | vasodilator |
| Uses | Fluorinated quinolone antibacterial |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
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- 2024-01-08
- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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