PYRVINIUM PAMOATE

Price	USD1.00
Packge	1kg

Product Details

Product NamePYRVINIUM PAMOATE
CAS No.3546-41-6
EINECS No.222-596-3
MFC75H70N6O6
MW1151.39
Appearancepowderred
storage temp. 2-8°C
Melting point 210-215° (softens at 190°)
Boiling point 829.27°C (rough estimate)
density 1.0104 (rough estimate)

Crystal 005

Product Name:	PYRVINIUM PAMOATE
Synonyms:	6-(dimethylamino)-2-(2-(2,5-dimethyl-1-phenylpyrrol-3-yl)vinyl)-1-quinoliniu;alnoxin;altolat;methyl-,saltwith4,4’-methylenebis(3-hydroxy-2-naphthoicacid)(2:1);molevac;neo-oxypate;pamovin;pirviniumpamoate
CAS:	3546-41-6
MF:	C75H70N6O6
MW:	1151.39
EINECS:	222-596-3
Product Categories:	POVAN
Mol File:	3546-41-6.mol

PYRVINIUM PAMOATE Chemical Properties

Melting point	210-215° (softens at 190°)
Boiling point	829.27°C (rough estimate)
density	1.0104 (rough estimate)
refractive index	1.6400 (estimate)
storage temp.	room temp
solubility	DMSO: >10mg/mL
color	red

Safety Information

Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38-40
Safety Statements	26-36

MSDS Information

PYRVINIUM PAMOATE Usage And Synthesis

Pharmacology and mechanism of action	Pyrvinium is a quaternary ammonium derivative of a cyanine dye with marked effect against Enterobius vermicularis. The mechanism of action is not well known. The drug inhibits oxidative metabolism in the worms and interferes with the absorption of glucose in intestinal helminths. Since most intestinal worms are dependent on anaerobic carbohydrate metabolism, this may be an important action of the drug^[1].
Indications	Infections caused by Enterobius vermicularis. Pyrvinium is largely replaced today by more effective and safer drugs such as albendazole and mebendazole.
Side effects	Gastrointestinal disturbances such as nausea, vomiting, dyspepsia, indigestion and abdominal pain are frequent. Allergic reactions and photosensitivity have been reported. Pyrvinium stains the stool bright red and may stain clothing if vomiting occurs. Patients should be informed about this.
Preparations	Pyrvinium pamoate (embonate): 450 mg of the pamoate is equivalent to 300 mg of pyrvinium. • Povanyl ® (Parke-Davis). Oral solution 10 mg pyrvinium per ml. Tablets 50 mg pyrvinium. • Vanquin® (Parke-Davis). Oral solution 10 mg pyrvinium per ml. Tab pyrvinium.
References	1. Buchanan RA, Barrow WB, Heffelfinger JC, Kinkel AW, Smith TC, Turner JL (1974). Pyrvinium pamoate. Clin Pharmacol Ther, 16, 716–719.
Uses	anthelmintic
Brand name	Povan (Parke-Davis).
General Description	Odorless bright orange or orange-red to brownish red or almost black fluffy powder. Melting point 210-215°C. Insoluble in water. Tasteless.
Air & Water Reactions	Insoluble in water.
Reactivity Profile	PYRVINIUM PAMOATE is light sensitive. Incompatible with strong oxidizing agents, strong acids and bases .
Fire Hazard	Flash point data for PYRVINIUM PAMOATE are not available; however, PYRVINIUM PAMOATE is probably combustible.

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.

Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.

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Product Details

Company Profile Introduction

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