BRUNEOMYCIN
| Price | USD1.00 |
| Packge | 1kg |
- Min. Order:1kg
- Supply Ability:100KG
- Time:2019-07-06
Product Details
- Product Name BRUNEOMYCIN
- CAS No.3930-19-6
- EINECS No.223-501-8
- MFC25H22N4O8
- MW506.46
- AppearanceA solidLight brown to brown
- storage temp. 2-8°C
- Melting point 301-303℃
- Boiling point 595.12°C (rough estimate)
- density 1.4130 (rough estimate)
AD68
| BRUNEOMYCIN Basic information |
| Product Name: | BRUNEOMYCIN |
| Synonyms: | rufocromomycin;streptonigrin from streptomyces flocculus;Streptonigrin, Streptomyces flocculus;Bruneomycin, Nigrin;5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxoquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid;BruneoMycin, Nigrin, RufocroMoMycin, Valacidin, RP 5278;5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid;Abbott Crystalline antibiotic |
| CAS: | 3930-19-6 |
| MF: | C25H22N4O8 |
| MW: | 506.46 |
| EINECS: | 223-501-8 |
| Product Categories: | |
| Mol File: | 3930-19-6.mol |
 |
|
| BRUNEOMYCIN Chemical Properties |
| Melting point | 301-303℃ |
| Boiling point | 595.12°C (rough estimate) |
| density | 1.4130 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | 2-8°C |
| pka | 6.2-6.4 (1:1 aq dioxane) |
| Merck | 13,8907 |
| Safety Information |
| Hazard Codes | T+ |
| Risk Statements | 28 |
| Safety Statements | 53-28-36/37/39-45 |
| RIDADR | UN 3462 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | TJ7350000 |
| F | 10-18 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| BRUNEOMYCIN Usage And Synthesis |
| Chemical Properties | Brown to red solid. Soluble in polar solvents and alkaline solutions; insoluble in most nonpolar solvents and acid solutions. |
| Uses | Streptonigrin is an unusual aminoquinone with broad biological activity against bacteria, fungi, nematodes, viruses and tumour cells. Streptonigrin acts as a bioreductive agent, highly dependent on interactions with metal ions, notably iron, and plays an important role in free radical production through redox cycling of NAD(P)H:quinone oxidoreductase (NQO1). |
| Uses | Streptonigrin is an unusual aminoquinone with broad biological activity against bacteria, fungi, nematodes, viruses and tumor cells. Streptonigrin acts as a bioreductive agent, highly dependent on interactions with metal ions, notably iron, and plays an important role in free radical production through redox cycling of NAD(P)H:quinone oxidoreductase (NQO1). |
| Definition | ChEBI: Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia. |
| Brand name | Nigrin (Pfizer). |
| Purification Methods | Streptonigrin is purified by TLC on pH 7-buffered silica gel plates (made from a slurry of Silica Gel 60 and 400mL of 0.05M phosphate buffer pH 7.0) and eluted with 5% MeOH/CHCl3. Material from the extracted band recrystallises from Me2CO or dioxane as almost black plates or needles. It is soluble in pyridine, Me2NCHO, aqueous NaHCO3 (some dec), and slightly soluble in MeOH, EtOH, EtOAc and H2O. It has UV max 248, 375-380nm ( 38,400 and 17,400). [Weinreb et al. J Am Chem Soc 104 536 1982, Rao et al. J Am Chem Soc 85 2532 1963.] Itis antineoplastic and causes severe bone marrow depression [Wilson et al. Antibiot Chemother 11 147 1961]. |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
INQUIRY