Lonidamine
| Price | USD1.00 |
| Packge | 1KG |
- Min. Order:1G
- Supply Ability:100KG
- Time:2019-07-06
Product Details
- Product NameLonidamine
- CAS No.50264-69-2
- EINECS No.256-510-0
- MFC15H10Cl2N2O2
- MW321.16
- AppearancesolidWhite
- Melting point 207-209°C
- storage temp. Sealed in dry,2-8°C
- density 1.4835 (rough estimate)
- Boiling point 537.9±45.0 °C(Predicted)
AD68
| Lonidamine Basic information |
| Product Name: | Lonidamine |
| Synonyms: | af1890;dica;doridamina;DICLONDAZOLIC ACID;LONIDAMINE;1-[2,4-DICHLOROBENZYL]-1H-INDAZOLE-3-CARBOXYLIC ACID;1-[(2,4-DICHLOROPHENYL)METHYL]-1H-INDAZOLE-3-CARBOXYLIC ACID;1-(2,4-Dichlorobenzyl)indazole-3-carboxylic acid |
| CAS: | 50264-69-2 |
| MF: | C15H10Cl2N2O2 |
| MW: | 321.16 |
| EINECS: | 256-510-0 |
| Product Categories: | API;DORIDAMINA;inhibitor;Anti-cancer&immunity |
| Mol File: | 50264-69-2.mol |
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| Lonidamine Chemical Properties |
| Melting point | 207-209°C |
| density | 1.4835 (rough estimate) |
| refractive index | 1.6070 (estimate) |
| storage temp. | Store at RT |
| CAS DataBase Reference | 50264-69-2(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | T |
| Risk Statements | 60-22-40 |
| Safety Statements | 53-22-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | NK7886000 |
| Toxicity | LD50 in mice, rats (mg/kg): 900, 1700 orally; 435, 525 i.p. (Heywood) |
| Lonidamine Usage And Synthesis |
| Description | Lonidamine is a derivative of indazole-3-carboxylic acid. It is a kind of orally administrated small molecule, which can inhibit the glycolysis process through inactivating the hexokinase (the first step in glycolysis). It has been shown that cancer cell primarily generates energy through glycolysis process. Therefore, Lonidamine has been used for the treatment of several kinds of cancers. One special property of Lonidamine is that it seems to enhance aerobic glycolysis in normal cells, but inhibit glycolysis only in cancer cells. In addition, there are also evidences that Lonidamine may increase the occurrence of apoptosis. It has also been shown that Lonidamine is effective in the treatment of benigh prostatic hyperplasia (BPH). |
| References | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1477623/ https://en.wikipedia.org/wiki/Lonidamine |
| Uses | contraceptive, spermicidal |
| Definition | ChEBI: A member of the class of indazoles that is 1H-indazole that is substituted at positions 1 and 3 by 2,4-dichlorobenzyl and carboxy groups, respectively. |
| Biological Activity | Anticancer and antispermatogenic agent in vitro and in vivo . Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl - channels in vitro . |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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