Fluvastatin sodium salt

Price	USD1.00
Packge	1KG

Product Details

Product NameFluvastatin sodium salt
CAS No.93957-55-2
EINECS No.1308068-626-2
MFC24H25FNNaO4
MW433.45
Appearancepowderwhite to tan
Melting point 194-197°C
storage temp. 2-8°C

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Fluvastatin sodium salt Basic information

Commonly used cholesterol-lowering drugs Chemical Properties Uses production method

Product Name:	Fluvastatin sodium salt
Synonyms:	(+/-)-(3R',5S',6E)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYLINDOL-2-YL]-3,5-DIHYDROXY-6-HEPTENOATE, SODIUM;FLUVASTATIN NA;FLUVASTATIN SODIUM;FLUVASTATIN SODIUM SALT;sodium (3r,5s,6e)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-2-yl]-3,5-dihydroxy-6-heptenoate;(r,s-(e))-monosodiumsal(+-)-2-yl);3,5-dihydro-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-6-heptenoicaci;5-dihydro-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-2-yl)-monosodiumsalt,(r,s-(e))-(6-heptenoicaci
CAS:	93957-55-2
MF:	C24H25FNNaO4
MW:	433.45
EINECS:	1308068-626-2
Product Categories:	Antihyperlipoproteinemic;Intermediates & Fine Chemicals;Pharmaceuticals;HMG-CoA reductase;API;API Reference Standard
Mol File:	93957-55-2.mol

Fluvastatin sodium salt Chemical Properties

Melting point	194-197°C
storage temp.	Desiccate at -20°C
solubility	H2O: ≥9mg/mL
color	white to tan
Merck	14,4218
InChIKey	ZGGHKIMDNBDHJB-RPQBTBOMSA-M
CAS DataBase Reference	93957-55-2(CAS DataBase Reference)

Safety Information

RTECS

MJ9675050

MSDS Information

Fluvastatin sodium salt Usage And Synthesis

Commonly used cholesterol-lowering drugs	Fluvastatin sodium salt is commonly used as a cholesterol-lowering drug, cholesterol-lowering effect is very good, the trade name of the commercially available products is Lescol,which is produced by Novartis. Fluvastatin sodium salt is a fully synthetic cholesterol-lowering drug, it belongs to methylglutaryl coenzyme A (HMC-CoA) reductase inhibitors, the main function is performed in the liver ,it can transform HMG-CoA into 3-methyl-3,5-dihydroxy acid, it can inhibit the synthesis of endogenous cholesterol ,and reduce cholesterol content in liver cells, it can stimulate the synthesis of low density lipoprotein (LDL) receptors,and enhance the uptake of LDL particles, reduce the plasma total cholesterol concentration.it can significantly reduce total cholesterol, LDL cholesterol, triglycerides, and increase high-density lipoprotein cholesterol. The above information is edited by the chemicalbook of Tian Ye.
Chemical Properties	Melting point 194~197 ℃.
Uses	HMG-CoA reductase inhibitors.
production method	1. After condensation of (chloroacetyl) fluorobenzeneand N-isopropyl aniline , the compound (I) is obtained. Then in acetonitrile, under the presence of phosphorus oxychloride, react with N, N-dimethylamino acrolein , the compound (Ⅱ) is obtained. Compound (Ⅱ) in the role of a strong base, after condensation with methyl acetoacetate , and then splitting ,the compound (Ⅲ) is produced. At-77 ~-74 ℃, the compound (Ⅲ) is added dropwise into a mixture of boron sodium borohydride , methanol, tetrahydrofuran and diethyl methoxy ,stir 30min; cyclic boronic ester obtained in ethyl acetate is treated with 30% hydrogen peroxide; then it is hydrolyzed to obtain fluvastatin sodium. 2. the compound (Ⅳ)is obtained by catalytic hydrogenation of Phloroglucinol . React it With tert-butyldiphenylsilyl chloride to produce the compound (V), and then oxidize it to generate (Ⅵ). After oxidation of chloroperbenzoic acid to obtain (Ⅶ), (Ⅷ) is produced through ring-opening . And then it is oxidized to (IX) . (Ⅺ) is obtained through condensation of (Ⅸ) and intermediate x , after deprotection and hydrolysis, obtain fluvastatin sodium. Intermediate (X) can be made through starting from the compound (I), via formylation, reduction, chlorination, and then reacting with triphenylphosphine .
Chemical Properties	Yellow Powder
Uses	A synthetic HMG-CoA reductase inhibitor. Antilipemic
Uses	Anti- hyperlipoproteinemic;'HMG CoA reductase inhibitor
Biological Activity	Orally active, potent and competitive HMG-CoA reductase inhibitor (IC 50 = 40 -100 nM at human liver microsomes). Inhibits vascular smooth muscle proliferation in vitro (IC 50 = 70 nM) and exhibits antihypercholesterolemic and antioxidant activity in vivo .

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.

Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.

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Product Details

Company Profile Introduction

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