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Methylparaben
Methylparaben

Methylparaben

Price USD1.00
Packge 1KG
  • Min. Order:1G
  • Supply Ability:100KG
  • Time:2019-07-06

Product Details

  • Product NameMethylparaben
  • CAS No.99-76-3
  • EINECS No.202-785-7
  • MFC8H8O3
  • MW152.15
  • InChIKeyLXCFILQKKLGQFO-UHFFFAOYSA-N
  • AppearanceCrystalline PowderWhite to almost white
  • Melting point 125-128 °C (lit.)
  • storage temp. room temp
  • Boiling point 298.6 °C
  • density 1,46g/cm
  • Water Solubility Slightly soluble in water.

AD68

Product Name: Methylparaben
Synonyms: NIPAGIN;NIPAGIN PLAIN;P-HYDROXYBENZOIC ACID METHYL ESTER;RARECHEM AL BF 0098;4-hydroxy-benzoicacimethylester;Abiol;Aseptoform;Benzoic acid, p-hydroxy-, methyl ester
CAS: 99-76-3
MF: C8H8O3
MW: 152.15
EINECS: 202-785-7
Product Categories: Aromatic Esters;Antioxidant;Biochemistry;Color Former & Related Compounds;Developer;Functional Materials;Aromatics;API;Other APIs;Cosmetics
Mol File: 99-76-3.mol
Methylparaben Structure
 
Methylparaben Chemical Properties
Melting point  125-128 °C(lit.)
Boiling point  298.6 °C
density  1,46g/cm
FEMA  2710 | METHYL P-HYDROXYBENZOATE
refractive index  1.4447 (estimate)
Fp  280°C
storage temp.  0-6°C
solubility  ethanol: soluble0.1M, clear, colorless
form  Crystalline Powder
color  White to almost white
Water Solubility  Slightly soluble in water.
FreezingPoint  131℃
Merck  14,6107
BRN  509801
Stability: Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKey LXCFILQKKLGQFO-UHFFFAOYSA-N
CAS DataBase Reference 99-76-3(CAS DataBase Reference)
NIST Chemistry Reference Benzoic acid, 4-hydroxy-, methyl ester(99-76-3)
EPA Substance Registry System Benzoic acid, 4-hydroxy-, methyl ester(99-76-3)
 
Safety Information
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22-36
Safety Statements  26-36-24/25-39
RIDADR  UN 2769
WGK Germany  1
RTECS  DH2450000
TSCA  Yes
HS Code  29182930
Hazardous Substances Data 99-76-3(Hazardous Substances Data)
Methylparaben Usage And Synthesis
Content analysis Method one: determinate according to the content analysis method in "butyl p-hydroxybenzoate (07002)". Per mL 1 mol/L sodium hydroxide is equivalent to the product (C8H8O3) 152.2mg.
Method two: Take 0.1 g (accurate to 1 mg) of the sample previously dried on silica gel for 5 h and move into a 300 ml flask with a glass plug. Plus l mol/L sodium hydroxide 10ml, heated in the water bath for 15min. After cooling, add 0.1mol/L potassium bromate 0.00ml, potassium bromide 5.0g and l mol/L hydrochloric acid 30ml. Put 15min in the dark room after sealing. Add potassium iodide 1 g, shake the flask vigorously, with 0.1mol/L sodium thiosulfate titration, with starch test solution (TS-235) as an indicator. Per ml 0.1mol/L potassium bromate is equivalent to the product (C8H8O3) 25.36mg.
Toxicity ADI 0～10mg/kg(FAO/WHO,2001).
GRAS(FDA,§184．1490，2000).
LD503000mg/kg(Dog, mouth)
Utilization limitation FAO/WHO (1984): Jam, jelly, 1000mg/kg (single or with benzoate, sorbic acid and potassium sorbate).
EEC(1990,mg/kg): For use in pigment solutions, flavor syrups, coffee extracts, frozen drinks, fruit, glucose and soft drinks, pickled fish, salad, sauce, snack food, concentrated soup and so on, limited to GMP; Beer 70; Snack cereals and soup concentrate 175, the same as "07018 p-hydroxybenzoate".
HACSG is listed as a restricted list.
FDA,§184.1490(2000):0.1%.
Chemical properties White needle crystal; Slightly soluble in water, easily soluble in ethanol, ether, acetone and other organic solvents.
Application
  • Antioxidants.
  • Antimicrobial agents for medicine and organic synthesis.
  • Anti-mildew in food, cosmetics and pharmaceutical industries.
  • As a preservative antiseptic agents in the pharmaceutical industry, also for organic synthesis and food, spices, film and other preservative additives.
  • Similar products produced by similar production methods, like ethyl p-hydroxybenzoate (paraben B) and propyl p-hydroxybenzoate (Nepalese c), are also disinfectant preservatives.The products are irritating to the skin.
Preparation The drug is esterified with p-hydroxybenzoic acid and methanol. The p-hydroxybenzoic acid was added to excess methanol to dissolve, stirring and adding concentrated sulfuric acid slowly. After heating and refluxing 10h, pour into the water to precipitate crystallization, then washed with water, sodium carbonate solution and water, finally obtain the crude product. Recrystallize from water or 25% ethanol to obtain finished product. The yield was 85%. Raw material consumption (kg/t): p-hydroxybenzoic acid 1200, methanol 1000.
Category Toxic Chemicals
Toxic grading Moderate toxicity
Acute toxicity Abdomen-mouse LD50: 960 mg/kg
Flammability hazard characteristics Combustible, excretes spicy smoke from fireground
Storage Ventilated , low temperature and dry warehouse.
Extinguishing agent Water, carbon dioxide, dry powder, sand.
Chemical Properties white crystalline powder
Uses It is used as preservative in foods, beverages and cosmetics.
Definition ChEBI: A 4-hydroxybenzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with methanol. It is the most frequently used antimicrobial preservative in cosmetics. It occurs naturally in several fruits, particularly in blu berries.
Uses As preservative in foods, beverages and cosmetics.
 

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
 
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
 

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  • Since:2014-12-17
  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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