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Citicoline sodium
Citicoline sodium

Citicoline sodium

Price USD1.00
Packge 1KG
  • Min. Order:1G
  • Supply Ability:100KG
  • Time:2019-07-06

Product Details

  • Product NameCiticoline sodium
  • CAS No.33818-15-4
  • EINECS No.251-689-1
  • MFC14H26N4O11P2.Na
  • MW511.31
  • Appearancesolidwhite
  • storage temp. -20°C
  • Melting point 259-268°C (dec.)
  • Water Solubility Soluble in water (100 mg/ml).

AD68

Citicoline sodium Basic information
Description Application
Product Name: Citicoline sodium
Synonyms: P'-[2-(TRIMETHYLAMMONIO)ETHYL]ESTER CYTIDINE 5'-(TRIHYDROGEN DIPHOSPHATE) INNER SALT MONOSODIUM;cytidine 5'-(trihydrogen diphosphate) p'-[2-(trimethylammonio)ethyl] ester inner salt monosodium salt;CYTIDINE-5'-DIPHOSPHOCHOLINE MONOSODIUM SALT;CYTIDINE-5'-DIPHOSPHOCHOLINE, NA;CYTIDINE-5'-DIPHOSPHOCHOLINE, SODIUM;CYTIDINE 5'-DIPHOSPHOCHOLINE SODIUM SALT;CYTIDINE 5'-DIPHOSPHOCHOLINE SODIUM SALT DIHYDRATE;CITICOLINE SODIUM SALT
CAS: 33818-15-4
MF: C14H25N4NaO11P2
MW: 510.31
EINECS: 251-689-1
Product Categories: Miscellaneous Natural Products;Bases & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;API
Mol File: 33818-15-4.mol
Citicoline sodium Structure
 
Citicoline sodium Chemical Properties
Melting point  259-268°C (dec.)
alpha  D20 +12.5° (c = 1.0 in H2O)
storage temp.  2-8°C
solubility  H2O: 100mg/mL
form  solid
color  white
Water Solubility  Soluble in water (100 mg/ml).
λmax 280nm(HCl aq.)(lit.)
Merck  13,2343
InChIKey YWAFNFGRBBBSPD-OCMLZEEQSA-M
 
Safety Information
Safety Statements  24/25
WGK Germany  3
F  3-10-21
Citicoline sodium Usage And Synthesis
Description Citicoline is a nucleic acid derivatives, Geiger found that citicoline can restore brain injury in the animal experiments in 1956. Kennedy study confirmed that citicoline can make brain injury recovery in 1957. Takeda pharmaceutical company in Japan developed and produced it in 1961. It was registered in China in 1988, and is currently the best-selling drug among clinical brain diseases. It plays an important role in the synthesis of lecithin, by promoting the synthesis of lecithin and improving brain function. Experiments show that citicoline can enhance the levels of norepinephrine and dopamine in the central nervous system, thereby it can treat cerebrovascular disease, traumatic brain injury and cognitive impairment caused by various reasons, and there are no obvious side effects.
Citicoline sodium can enhance the function of brain stem reticular formation, especially the ascending reticular activating system associated with human consciousness; enhance the function of the pyramidal system; inhibit the function of the external system of the cone, and promotes the recovery of the function of the system. For the treatment of sequelae of traumatic brain injury and cerebral vascular accident caused by the nervous system, it can also be used in the treatment of Parkinson's disease, senile dementia has a certain effect; for the treatment of cardiovascular and cerebrovascular diseases; it also have a certain effect for anti-aging, improving learning and memory.
Application
  • Central nervous system medication.
  • Coenzyme. For acute traumatic brain injury and brain surgery consciousness. Acute brain injury and brain surgery after a disturbance of consciousness, paralysis due to stroke can gradually restore the function of the limbs, it can also be used for functions and other central nervous system disorders of consciousness caused by acute injury, and also for ischemic cerebrovascular disease and vascular dementia.
Chemical Properties White Solid
Uses Naturally occurring nucleotide; intermediate in the major pathway of lecitin biosynthesis. Neuroprotective. It is used in the treatment of ischemic stroke and head trauma.
Uses Cytidine 5′-diphosphate (CDP) is used as a substrate of CDP (nucleoside diphosphate) kinase (2.7.4.6) to produce CTP in support ofDNA and RNA biosynthesis and of ribonucleotide reductase to product dCMP.

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate,  is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
 
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
 

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Henan China
  • Since:2014-12-17
  • Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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