Trifluoromethanesulfonic acid
| Price | USD1.00 |
| Packge | 1KG |
- Min. Order:1G
- Supply Ability:100KG
- Time:2019-07-06
Product Details
- Product NameTrifluoromethanesulfonic acid
- CAS No.1493-13-6
- EINECS No.216-087-5
- MFCHF3O3S
- MW150.08
- InChIKeyITMCEJHCFYSIIV-UHFFFAOYSA-N
- AppearanceFuming Liquidslightly brown
- Melting point -40 °C
- Water Solubility SOLUBLE
- Boiling point 162 °C (lit.)
- storage temp. Store below +30°C.
- density 1.696 g/mL at 25 °C (lit.)
AD68
| Trifluoromethanesulfonic acid Basic information |
| Product Name: | Trifluoromethanesulfonic acid |
| Synonyms: | Fluorad FC-24;Methanesulfonic acid, trifluoro-;trifluoromethanesulfonic;trifluoro-methanesulfonicaci;PERFLUOROMETHANESULFONIC ACID;PFC-MS;TRIFLUOROMETHANESULPHONIC ACID;TRIFLUOROMETHANESULFONIC ACID |
| CAS: | 1493-13-6 |
| MF: | CHF3O3S |
| MW: | 150.0770496 |
| EINECS: | 216-087-5 |
| Product Categories: | straight chain compounds;Organic Fluorides;Organic AcidsVolumetric Solutions;Reference Material Potassium hydrogenphthalateTitration;Acid SolutionsChemical Synthesis;By Reference Material;Solutions for non-aqueous titrations;Synthetic Reagents;Titration;Volumetric Solutions;organofluorine compounds;Pharmaceutical intermediates |
| Mol File: | 1493-13-6.mol |
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| Trifluoromethanesulfonic acid Chemical Properties |
| Melting point | -40 °C |
| Boiling point | 162 °C(lit.) |
| density | 1.696 g/mL at 25 °C(lit.) |
| vapor density | 5.2 (vs air) |
| vapor pressure | 8 mm Hg ( 25 °C) |
| refractive index | n20/D 1.327(lit.) |
| RTECS | PB2771000 |
| Fp | None |
| storage temp. | −20°C |
| solubility | Miscible in H<sub>2</sub>O |
| pka | -14(at 25℃) |
| form | Fuming Liquid |
| color | slightly brown |
| PH | <1 (H2O) |
| Water Solubility | SOLUBLE |
| Sensitive | Hygroscopic |
| Merck | 14,9676 |
| BRN | 1812100 |
| Stability: | Stable. Incompatible with acids, alkalis, metals. |
| InChIKey | ITMCEJHCFYSIIV-UHFFFAOYSA-N |
| CAS DataBase Reference | 1493-13-6(CAS DataBase Reference) |
| NIST Chemistry Reference | CF3SO3H(1493-13-6) |
| Safety Information |
| Hazard Codes | C |
| Risk Statements | 21/22-35-10 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 3265 8/PG 2 |
| WGK Germany | 2 |
| F | 3-10 |
| Hazard Note | Corrosive/Hygroscopic |
| TSCA | Yes |
| HazardClass | 8 |
| PackingGroup | II |
| HS Code | 29049020 |
| Trifluoromethanesulfonic acid Usage And Synthesis |
| Description | Trifluoromethanesulfonic acid, also known as triflic acid, TFMS, TFSA, HOTf or TfOH, is a sulfonic acid with the chemical formula CF3SO3H. It is often regarded as one of the strongest acids, and is one of a number of so-called "superacids". it is used in the manufacture of pharmaceuticals, agricultural chemicals and polymers. The anhydrous form is widely used in fine chemical synthesis. It is non-oxidizing, has a high thermal stability, and is resistance to both oxidation and reduction, which makes it one of the more useful compounds in the super acids class. In the pharma industry, it is used to make a number of drug classes, including nucleosides, antibiotics, steroids, proteins and glycosides. Triflic anhydride reacts readily with water and has an unfavorable toxicity profile. |
| Chemical Properties | Trifluoromethanesulfonic acid is a hygroscopic, colorless liquid at room temperature. It is soluble in polar solvents such as dimethylformamide (DMF), dimethyl sulfoxide (DMSO), acetonitrile, and dimethyl sulfone. Addition of triflic acid to polar solvents can be dangerously exothermic. Trifluoromethanesulfonic acid is widely used especially as a catalyst and a precursor in organic chemistry. With an Ka = 8. 0 1014 (pKa ~ -15) mol/kg, HOTf qualifies as a superacid. Triflic acid owes many of its useful properties to its great thermal and chemical stability. Both the acid and its conjugate base CF3SO3-, known as triflate, resist oxidation/reduction reactions, whereas many strong acids are oxidizing, e. g. HClO4 and HNO3. The triflate anion is immune to attack by even strong nucleophiles. Because of its resistance to oxidation and reduction, triflic acid is a very useful and versatile reagent. Further recommending its use, triflic acid does not sulfonate substrates, which can be a problem with sulfuric acid, fluorosulfuric acid, and chlorosulfonic acid. Below is a prototypical sulfonation, which HOTf does not undergo: C6H6 + H2SO4 → C6H5(SO3H) + H2O. |
| Preparation | Yellow-brown liquid. The boiling point is 167~170 ℃.The refractive index is 1.331.The relative density is 1.708.It is the strongest organic acids, easily soluble in water.Use carbon disulfide as raw material, with the reaction of iodine pentafluoride to produce trifluoromethyl disulfide.(CF3S) 2Hg was obtained when reacting with mercury; Then through oxidation of hydrogen oxide, trifluoromethanesulfonic acid is acquired. |
| Uses |
|
| Reactions | Trifluoromethanesulfonic acid acts as a catalyst for esterification reactions and an acidic titrant in nonaqueous acid-base titration. It is useful in protonations due to the presence of conjugate base triflate is non nucleophilic. It serves as a deglycosylation agent for glycoproteins. In addition, it is a precursor and a catalyst in organic chemistry. It reacts with acyl halides to prepare mixed triflate anhydrides, which are strong acylating agents used in Friedel-Crafts reactions. It acts as a key starting material for the preparation of ethers and olefins by reacting with alcohols as well as to prepare trifluoromethanesulfonic anhydride by dehydration reaction. Catalyst used in the production of cocoa butter substitute from palm oil. This is a very similar reaction to what would be done if one wanted to create polymers using triflic acid in the synthesis. Other Friedel-Crafts type reactions using triflic acid include cracking of alkanes and alkylation of alkenes which are very important to the petroleum industry. These triflic acid derivative catalysts are very effective in isomerizing straight chain or slightly branched hydrocarbons that can increase the octane rating of a particular petroleum based fuel. |
| Chemical Properties | Clear very light yellow liquid |
| Uses | Acid catalyst for the industry, Intermediate for liquid crystals, Pharmaceuticals intermediates, Intermediate for organic synthesis. One of the strongest available monoprotic acids. |
| Uses | As a catalyst in Friedel-Crafts type acylation, alkylation and polymerization reactions; as a solvent for ESR; as a nonaqueous strong acid titrant; with trifluoroacetic acid, q.v., in solid-phase peptide synthesis. |
| Definition | ChEBI: A one-carbon compound that is methanesulfonic acid in which the hydrogens attached to the methyl carbon have been replaced by fluorines. |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
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- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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