Naproxen
| Price | USD1.00 |
| Packge | 1KG |
- Min. Order:1G
- Supply Ability:100KG
- Time:2019-07-06
Product Details
- Product NameNaproxen
- CAS No.22204-53-1
- EINECS No.244-838-7
- MFC14H14O3
- MW230.26
- InChIKeyCMWTZPSULFXXJA-DJEYLCQNNA-N
- AppearancepowderWhite to Almost white
- Melting point 152-154 °C (lit.)
- storage temp. 2-8°C
- Water Solubility Insoluble in water.
- Boiling point 332.25°C (rough estimate)
- density 1.1450 (rough estimate)
AD68
| Naproxen Basic information |
| Product Name: | Naproxen |
| Synonyms: | ()-2-(methoxy-2-naphthyl)-propionicacid;()-2-(methoxy-2-naphthyl)-propionsaeure;()-propionicaci;(+)-2-(Methoxy-2-naphthyl)-propionic acid;(+)-2-(methoxy-2-naphthyl)-propionicacid;(+)-2-(Methoxy-2-naphthyl)-propionsaeure;(+)-2-naphthaleneaceticaci;(+)-6-Methoxy-alpha-methyl-2-napthaleneacetic acid |
| CAS: | 22204-53-1 |
| MF: | C14H14O3 |
| MW: | 230.26 |
| EINECS: | 244-838-7 |
| Product Categories: | chiral;Carboxylic Acids (Chiral);Chiral Building Blocks;for Resolution of Bases;Optical Resolution;Synthetic Organic Chemistry;Intermediates & Fine Chemicals;Pharmaceuticals;Lipid signaling;Aromatics;ALEVE;Other APIs |
| Mol File: | 22204-53-1.mol |
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| Naproxen Chemical Properties |
| Melting point | 152-154 °C(lit.) |
| alpha | D +66° (in chloroform) |
| Boiling point | 332.25°C (rough estimate) |
| density | 1.1450 (rough estimate) |
| refractive index | 67.5 ° (C=1, CHCl3) |
| Fp | 9℃ |
| storage temp. | -20°C Freezer |
| Water Solubility | Insoluble in water. |
| Merck | 14,6417 |
| BRN | 3591067 |
| CAS DataBase Reference | 22204-53-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Naproxen(22204-53-1) |
| Safety Information |
| Hazard Codes | Xn,T,F |
| Risk Statements | 22-39/23/24/25-23/24/25-11-36/37/38 |
| Safety Statements | 36/37-45-16-7-26 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | UF5275000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Hazardous Substances Data | 22204-53-1(Hazardous Substances Data) |
| Toxicity | LD50 in mice (mg/kg): 435 i.v.; 1234 orally; in rats (mg/kg): 575 i.p.; 534 orally (Roszkowski) |
| Naproxen Usage And Synthesis |
| Non-steroidal anti-inflammatory drugs | Naproxen is a non-steroidal anti-inflammatory drug ,it is a PG synthase inhibitor, which can inhibit prostaglandin synthetase, it has significant analgesic and antipyretic effects, oral absorption is rapid and complete, 2 to 4 hours after a dose ,plasma concentration reaches the peak, in the blood , more than 99% is bound to plasma proteins, t1/2 is 13 to 14 hours, about 95% is discharged from the urine with the prototype and metabolites.it is clinically used For the treatment of rheumatic and rheumatoid arthritis , osteoarthritis, ankylosing spondylitis, gout, arthritis, tenosynovitis.it can also be used to alleviate pain caused by musculoskeletal sprains, contusions,damages and dysmenorrhea . But it should be noted that like other non-steroidal anti-inflammatory drugs, the same serious gastrointestinal adverse reactions could occur at any time while taking naproxen during treatment, so the active gastroduodenal ulcer patients are hanged, other gastrointestinal tract disease patients should take this drug under close medical supervision. The above information is edited by the Chemicalbook of Tian Ye. |
| Chemical Properties | White crystal or crystalline powder. Melting point 155.3 ℃. Soluble in acetone, soluble in methanol, ethanol, acetic acid, insoluble in benzene, practically insoluble in water. In case of light,it is color-graded, odorless, tasteless. |
| Uses | It is a non-steroidal anti-inflammatory drug for the relief of fever and inflammation and pain associated with arthritis or other symptoms , it has anti-inflammatory, antipyretic and analgesic effects. Naproxen plays a role by inhibiting the cyclooxygenase, which generates prostaglandin and is one kind of enzymes related to inflammatory mediators . It is recommended to take the drug during meals to reduce stomach irritation. |
| Used in Particular Diseases | Acute Gouty Arthritis: Dosage and Frequency: 500 mg twice daily for 3 days, then 250–500 mg daily for 4–7 days |
| production method | by methylation, acetylation With 2-naphthol , 6-methoxy-2-acetonaphthone is produced, then it is condensed with acid ester, then generate the product through isomerization, hydrolysis, oxidation, and split and other reactions. |
| Category | Toxic substances |
| Toxicity grading | Highly toxic |
| Acute toxicity | Oral-rat LD50 248 mg/kg; Oral-Mouse LD50: 360 mg/kg |
| Flammability and hazard characteristics | Combustible; combustion produces toxic and acrid smoke. |
| Storage Characteristics | Ventilated, low-temperature ,dry storeroom, it should be stored and transported from food raw materials separately. |
| Extinguishing agent | Water, dry powder, foam,sand |
| Chemical Properties | white to light yellow crystal powde |
| Uses | An anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory |
| Definition | ChEBI: A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such a osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes. |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
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- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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