Lubiprostone
| Price | USD1.00 |
| Packge | 1KG |
- Min. Order:1KG
- Supply Ability:1
- Time:2019-07-06
Product Details
- Product NameLubiprostone
- CAS No.136790-76-6
- EINECS No.634-172-9
- MFC20H32F2O5
- MW390.47
- Appearancepowderwhite to beige
- Melting point 56-59°C
- storage temp. -20°C
- Boiling point 539.1±50.0 °C(Predicted)
- density 1.143±0.06 g/cm3(Predicted)
CR368
| Product Name: | Lubiprostone |
| Synonyms: | Lubiprostone API;7-[(1r,4r,6r,9r)-4-(1,1-difluoropentyl)-4-hydroxy-8-oxo-5-oxabicyclo[4.3.0]non-9-yl]heptanoic acid;lubiprostone;(11a)-16,16-Difluoro-11-hydroxy-9,15-dioxo-prostan-1-oic Acid;Ru 0211;C13707;(11α)-16,16-Difluoro-11-hydroxy-9,15-dioxo-prostan-1-oic Acid;Prostan-1-oic acid, 16,16-difluoro-11-hydroxy-9,15-dioxo-, (11α)- |
| CAS: | 136790-76-6 |
| MF: | C20H32F2O5 |
| MW: | 390.4618864 |
| EINECS: | |
| Product Categories: | Inhibitors;Prostaglandin;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Other APIs |
| Mol File: | 136790-76-6.mol |
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| Lubiprostone Chemical Properties |
| Melting point | 56-59°C |
| storage temp. | -20°C Freezer |
| Safety Information |
| Lubiprostone Usage And Synthesis |
| Description | Marketed under the trade name Amitiza, Lubiprostone is a chloride channel activator which is mainly used for the treatment of idiopathic (due to an unknown cause) chronic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. Lubiprostone is an oral medication approved by the FDA in January 2006. The mechanism of action of lubiprostone is the same as chloride channel activator. It functions by binding and activating ClC-2 chloride channels in the apical membrane of the gastrointestinal epithelium, which produces an efflux of chloride-rich fluid secretion. The increased amounts of secretions are effective to soften the stool, increase motility, promote spontaneous bowel movements (SBM), and speed up transit of stool in the colon. Therefore, the relevant symptoms, such as abdominal pain and bloating, can be reduced. |
| References | https://en.wikipedia.org/wiki/Lubiprostone http://www.medicinenet.com/lubiprostone/article.htm https://www.drugbank.ca/drugs/DB01046 https://pubchem.ncbi.nlm.nih.gov/compound/157920#section=Top |
| Chemical Properties | White Solid |
| Uses | A locally acting chloride channel activator for the treatment of gastrointestinal disorders |
| Uses | Lubiprostone is a bicyclic fatty acid metabolite analog of Prostaglandin E1. It activates specific chloride channels in the gastrointestinal tract to stimulate intestinal fluid secretion, increase gastrointestinal transit, and improve symptoms of constipation. |
Company Profile Introduction
Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.
Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.
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- Since:2014-12-17
- Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho
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