AICAR

Price	USD1307.00
Packge	100G

Min. Order:1G
Supply Ability:customise
Time:2019-07-06

Product Details

Product NameAICAR
CAS No.2627-69-2
EINECS No.220-097-5
MFC9H14N4O5
MW258.23
Appearancepowdertan
storage temp. -20°C
Melting point 214-215 °C
Water Solubility Soluble in DMSO at 2mg/ml. Soluble in water or ethanol at less than 1mg/ml
Boiling point 726.3±60.0 °C(Predicted)
density 2.06±0.1 g/cm3(Predicted)

WM0050

AICAR Basic information

adenosine regulating agents

Product Name:	AICAR
Synonyms:	ACADESINE;AICAR;AICA-RIBOSIDE;AMPK;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-RIBOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-B-D-RIBOFURANOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE 1-BETA-D-RIBOFURANOSIDE;Z-RIBOSIDE
CAS:	2627-69-2
MF:	C9H14N4O5
MW:	258.23
EINECS:	220-097-5
Product Categories:	Bases & Related Reagents;Carbohydrates & Derivatives;Nucleotides;Protein Kinase;ARASINE;Cardiovascular APIs;PI3K/Akt/mTOR;Akt;mTOR;PI3K
Mol File:	2627-69-2.mol

AICAR Chemical Properties

Melting point	214-215 °C
storage temp.	−20°C
solubility	H₂O: >10 mg/mL
form	powder
color	tan
Water Solubility	Soluble in DMSO at 2mg/ml. Soluble in water or ethanol at less than 1mg/ml
λmax	265nm(NaOH)(lit.)
Merck	14,16
InChIKey	RTRQQBHATOEIAF-UUOKFMHZSA-N
CAS DataBase Reference	2627-69-2(CAS DataBase Reference)
EPA Substance Registry System	1H-Imidazole-4-carboxamide, 5-amino-1-.beta.-D-ribofuranosyl- (2627-69-2)

Safety Information

Hazard Codes	Xi,T
Risk Statements	36/37/38-61
Safety Statements	26-36-45-53
WGK Germany	3
TSCA	Yes

MSDS Information

Provider	Language
SigmaAldrich	English

AICAR Usage And Synthesis

adenosine regulating agents	Acadesine is the prototype of a new class of compounds termed adenosine regulating agents. Acadesine is a purine nucleosid analogue that enters the myocyte and is immediately phosphorylated to ZMP (AICA ribotide), which is further metabolised to Inosine mono-phosphate (an intermediate in the synthesis ofadenosine triphosphate (ATP) and guanosine triphos-phate). Claims that acadesine may serve as a substrate for ATP synthesis and result in repletion of myocardial ATP were supported by some studies and refuted by others. Because acadesine may be a precursor in the synthesis of myocardial ATP it was proposed as a possible agent of myocardial protection during ischaemia, particularly because myocardial ATP depletion has been linked to cell death.
Chemical Properties	Solid
Uses	glucose uptake stimulant; AMPK activator
Uses	AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.
Definition	ChEBI: A 1-ribosylimidazolecarboxamide in which the carboxamide group is situated at position 4 of the imidazole ring, which is further substituted at position 5 by an amino group. A purine nucleoside analogue and activator of AMP-activated protein kinase, it is is used for the treatment of acute lymphoblastic leukemia and is reported to have cardioprotective effects.
Biological Activity	Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes.

Company Profile Introduction

Henan CoreyChem Co., Ltd, based on the original Zhengzhou Cote Chemical Research Institute, be brave in absorbing highly educated talents & overseas returnees; actively responded to Zhengzhou City High-tech Zone Government’s Special Care Policy, reorganized and founded in National University of Science and Technology Park, which is a high-tech, stock enterprise of high-end chemical Custom synthesis;The park was created by the People's Government of Henan Province, and proved by Ministry of Education and the National Science & Technology, taking the construction mode of "many college a park, and common development", mainly depends on Zhengzhou University and Henan University’s scientific research and talent advantage to set up Universities, scientific research institute and enterprise scientific research achievements transformation platform, to make high-tech enterprises incubate, is the new high-tech talent gathering base, high and new technology industry enterprise radiation base, colleges and universities technological innovation base.

Henan Coreychem Co., Ltd, facing global High-tech pharmaceutical raw materials, high complex new type intermediates, fine chemicals custom synthesis, scale-up production and Rare chemicals trade. Corey have well-equipped machine, strong technical force and considerate marketing team service. We also have rich experience advantage in basic research, small scale process development, scale-up, industrial technology development & production and cost control.

career henan chemical co

Henan China

Since:2014-12-17
Address: No.967,15th Floor,Unit 7, Building 1, No.70 of DianChang Road, High-tech Development Zone, Zhengzho

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