Laboratory Production of GS-441524 to Treat FIP
| Price | USD33.00 |
| Packge | 10PCS |
- Min. Order:10PCS
- Supply Ability:1000kgs
- Time:2022-03-08
Product Details
- Product NameGS-441524
- CAS No.1191237-69-0
- EINECS No.200-001-8
- MFC12H13N5O4
- MW291.26
- AppearancesolidOff-white
- density 1.84±0.1 g/cm3(Predicted)
- storage temp. -20°C
- Melting point > 233° C (dec.)
Laboratory Production of GS-441524 to Treat FIP
Basic Information
 GS-441524 structure | Common Name | GS-441524 | ||
|---|---|---|---|---|
| CAS Number | 1191237-69-0 | Molecular Weight | 291.26 | |
| Density | 1.84±0.1 g | Boiling Point | N/A | |
| Molecular Formula | C12H13N5O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
How GS441 Cures FIP
If a cat's immune system is healthy and mature, the white blood cells should fight off an infection or virus, and allow the cat to build up an immune response, or antibodies. Cats who develop FIP have an immune defect or deficiency that causes the white blood cells to replicate, rather than fight, the virus. Essentially, the cats immune system is spreading the virus throughout the cat's body rather than trying to eliminate it. Cats who have no immune response develop wet FIP, while cats who have a partial immune response develop dry FIP.
The nucleoside analog GS-441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. In layman's terms, GS441 interjects itself into the chain reaction and stops the replication of the virus.
Dr Pedersen's case study determined that a successful course of treatment with GS441 is 12 weeks, administered daily. Some owners have stopped treating once blood work and diagnostics returned to normal; however, the few cats who did relapse were among those who stopped prior to the 12 week protocol. Because the course of treatment is both emotionally and financially taxing, most owners currently using GS opt to pursue the full 12 weeks, to ensure the highest probability of success. Cats who undergo the full 12 weeks and remain symptom-free for 90 days following conclusion of treatment are officially cured of FIP.
GS441 comes in both injectable form, and as of June 2019, a pill form. Both are administered daily and the dose is based on the weight of the cat.
For wet & dry FIP without neurological or ocular symptoms, the recommended dosage is 5mg (GS) x weight (kg) / GS concentration per 1mL = dose per 24 hr.
Neurological and Ocular FIP cats require 7mg/kg MINIMUM, and can go as high as 10mg/kg for extreme ocular or neurological cases.
A dosing calculator can be found here.
It is important to note that the dosage should not be reduced during the course of treatment, regardless of how well the cat is responding.
Conversely, if the cat is not responding to the starting dosage, it is safe to increase. It is also crucial to check the cat's weight often, and adjust the daily dose accordingly.
The only known side effect of GS441 is skin lesions or burns, due to the acidity of the solution (injectable form). For this reason, it is recommended to always clean the cat's skin after giving an injection. Many owners also opt to give oral CBD oil or Hemp oil 30-60 minutes before injecting, to help minimize the stress. Should you opt to do this, it is critical that the product be veterinary grade and the proper dose should be determined by a veterinarian. CBD and/or hemp oil can be fatal to a cat if not administered properly. More commonly, Gabapentin, a mild pain medication can be given orally 60-90 minutes prior to the injection. The vast majority of cats using GS tolerate the injections just fine without the need for any pain medication or sedative.
Supportive Care
While we've seen first hand that GS is a miracle drug, it's not the end-all-be-all. You still need to support your cat's well-being while waiting for GS to arrive and until your cat starts to respond to it. Proper supportive care can make all the difference as to whether or not the cat survives. Lack of proper supportive care can cause further complications, up to and including death.
Cats need to consume minimally 200 calories per day and 60 ml of water per day. Anemia needs to be treated, whether via B12 or possibly a transfusion, depending on severity. Fluids may need to be drained. Fevers need to be monitored and reduced. For additional information about crucial home care and supportive care of FIP cats, please continue here.
Supplemental Care When Using GS441 to Cure FIP
In general, unless the cat has a secondary or underlying condition besides FIP, all prescription medications can be stopped once treatment with GS begins. However, all cats, FIP or not, can benefit from a high quality probiotic such as Fortiflora. A healthy gut is essential in fighting FIP and can help stave off so many other illnesses too.
For additional information on overall wellness and support, please view the vitamins and supplements page.
Palliative Care For Cats With FIP
We understand that there are many reasons why someone may not want to use GS441. While it is highly effective, it is also still experimental and in many circumstances, cost prohibitive.
For those who wish to provide palliative treatment to their FIP cat, there are several options available.
Polyprenyl Immunostimulant
Polyprenyl Immunostimulant, or "PI" as it is commonly referred to in the FIP groups, is an oral supplement that is administered daily for 1-2 weeks, then every other day once the jump-start dose is completed. PI is approved to treat feline herpes; however, it is used off-label to treat feline infectious peritonitis. It is not a cure of FIP, but there have been some long term FIP survivors. PI is best suited for dry FIP, and the success rate (defined as surviving 1 year or more) is approximately 10%.
Polyprenyl is used to enhance and strengthen the cat's immune system, ideally to allow the cat to fight off the virus.
Cats who are using Polyprenyl should also be receiving overall systemic support by way of weekly B12 injections, daily B12 supplements, and if and as needed, appetite stimulants and ant-nausea medication. Typically an anti-viral medication will also be prescribed for 10-14 days.
PI must be prescribed and ordered by a veterinarian. The necessary forms and ordering information can be found on Vet Immune's website.
*Cats who are taking Polyprenyl for FIP should NOT be taking steroids, as steroids will weaken the cat's immune system and work against the PI.
Steroid Treatment for FIP
For many years, steroid treatment was the only option for FIP cats. It is entirely palliative in nature, i.e. it's purpose is to keep the cat comfortable for however much time he/she has left.
Steroids are inexpensive and can help provide temporary comfort to an FIP cat by increasing appetite, reducing fever, reducing inflammation, and with wet FIP, steroids may also help to reduce the effusion.
Home Care/Supportive Care
The success of palliative care, as well as your cat's quality of life, depends highly on supportive care and treating symptoms such as inappetence, fever, anemia, diarrhea and more. Please continue reading about supportive care here.
Contact us
Our Company
Shanghai Biolang Biological Co., Ltd has a registered capital of 1 million yuan and is one of the most dynamic foreign trade companies in the Chinese market. We have a pharmaceutical raw material production plant and a reagent R&D center. We now have the most complete product line. In addition, we have developed and produced tens of thousands of reagents. We also have the business of custom synthesis of various organic compounds as a supplement. We can synthesize almost all chemicals. Our goal is to survive by quality and develop by credit.
In the past two years, our products have spread over more than 30 countries in the world, Europe, South America, North America, Southeast Asia and Africa. We work with friends all over the world to develop the best quality products, the most reasonable prices and safe and effective transportation. Product can be ordered from milligrams to tons. Meet the purchase of new and old customers. We will not let you down.
Payment & Delivery
Why choose us?
1. Products with high purity and good quality
2. Choose the most suitable price according to customer needs to achieve a win-win situation.
3. Spot samples can be shipped quickly after payment, saving time for receiving goods.
4. Track the transportation of goods throughout the process
5. Safe raw materials from China
6. Have professional customs clearance capabilities and the best pre-sales and after-sales services.
our service
1. Cooperate with scientific research institutes and major factories to strictly control the entire process of products from raw materials to finished products
2. Customer first, we provide reasonable prices, high-quality products and timely delivery.
3. We can send the goods directly to your receiving address.
4. Quickly and accurately answer customers' doubts
5. If you place a large number of orders with us, we can provide preferential prices
6. Products can be packaged according to customer requirements.
FAQ
Q1: Can I get some samples?
Answer: Yes, we can provide free samples, but the freight is paid by our customers.
Q2: How to confirm the product quality before placing an order?
Answer: You can get samples of some products for free, you only need to pay the freight or arrange express delivery to us and get the samples. You can send us your product specifications and requirements, and we will manufacture products according to your requirements.
Q3: How to start an order or payment?
After the order is confirmed, the PI will be sent first with our bank information. Payment via T/T, Western Union, Letter of Credit, Alibaba Trade Assurance, Cashapp, Moneygram or Bitcoin.
Q4: How to place an order?
You can contact me through Trademanager, WhatsApp, Skype Online and other contact methods, tell me the product and quantity you need, and we will give you a quote. If you choose one of the above payment methods, we will arrange delivery for you.
Q5: Are there any discounts?
Answer: There are different discounts for different quantities.
Q6: How about your delivery time?
Answer: Generally speaking, it will take 3 to 5 days after receiving your prepayment. (Excluding Chinese holidays)
Q6: How do you deal with quality complaints?
Answer: First of all, our quality control will reduce quality problems to close to zero. If the quality problem is indeed caused by us, we will replace it for you free of charge or refund your loss.
Company Profile Introduction
Shanghai Biolang was established in 2004. Its headquarter and foreign trade department are located in Shanghai, its R&D center is located in Optics Valley Bio-City, its logistics center is located in Wuhan Biomedical Park, and its production bases are located in Luotian, Tongshan, Dongying, Pingxiang and other places. Beilang Bio's business involves the research and development of innovative drugs, the screening of compound crystal forms, the custom synthesis of pharmaceutical intermediates and APIs, and the import and export business, as well as the outsourcing procurement and agent sales of pharmaceutical chemicals. In order to better serve customers, Beilang Bio has assembled a R&D team composed of 5 Ph.Ds, which can carry out process development and pilot scale-up production of multiple projects at the same time. At the same time, it has established more than 5,000 square meters of cGMP production. The base has passed the FDA's ready-made review, which can realize the g-kg-t rapid response of pharmaceutical intermediates. Not only that, it has also built a 1,000-square-meter logistics center in Wuhan, a thoroughfare of nine provinces, and has a spot reserve worth more than 10 million. , It can realize the quick response to 1w orders in a single day. Beilang Biology has cooperated with many well-known universities and scientific research institutions such as Wuhan University, Shanghai University, China Medical University, China Pharmaceutical University, Shenyang Pharmaceutical University, Shanghai Institutes of Biological Sciences, China Institute of Biotechnology in the development of new drugs. Cooperation. At the same time, it has extensively cooperated with major pharmaceutical companies such as CSPC, Huayao Group, and Langbo Pharmaceutical to jointly develop export business. For a long time, colleagues regard Beilang as a long-term and reliable partner. We also hope to carry out more cooperation with colleagues in the industry, and work towards a better tomorrow.
- Since:2015-12-25
- Address: Room D621, Building 7, No. 228, Jingle Road, Langxia Town, Jinshan District, Shanghai