2-Picolinic acid Sorafenib Impurity 18 PCL 016
| Price | USD1.99 |
| Packge | 10KG |
- Min. Order:1KG
- Supply Ability:400tons
- Time:2022-07-21
Product Details
- Product Name2-Picolinic acid
- CAS No.98-98-6
- EINECS No.202-719-7
- MFC6H5NO2
- MW123.11
- InChIKeySIOXPEMLGUPBBT-UHFFFAOYSA-N
- AppearanceCrystalline PowderWhite to almost white
- Water Solubility 887 g/L (20 ºC)
- storage temp. Store below +30°C.
- Melting point 139-142 °C (lit.)
- Boiling point 229.19°C (rough estimate)
- density 1.3147 (rough estimate)
| Description | PCL 016 is a topical antiviral agent, which inhibits adenovirus replication in rabbit. |
|---|---|
| Related Catalog | |
| Target | Human Endogenous Metabolite |
| In Vivo | Topical 1.5% PCL, 0.8% PCL, 0.369% PCL (pH7), 0.369% PCL (pH4) and 0.5% CDV are significantly more effective than the Control in reducing Ad Positive Cultures/Total (Days 1-14) and the Duration of Ad Shedding in the Ad5/NZW rabbit ocular model. Although not statistically significant, there appears to be a trend toward concentration-dependent efficacy of PCL 016 on the Duration of Ad Shedding. There is no apparent ocular toxicity associated with PCL 016 concentrations[1]. |
| Animal Admin | Rabbits[1] 25 NZW rabbits are topically inoculated in both eyes, following corneal scarification, with 1.5 x 106 pfu/eye of Ad5. On day 1, the rabbits are divided into 6 topical treatment groups: I - 1.5% PCL 016 pH 7.0 (n=4); II - 0.8% PCL 016 pH 7.0 (n=4); III - 0.369% PCL 016 pH 7.0 (n=4); IV - 0.369% PCL 016 pH 4.0 (n=4); V - 0.5% Cidofovir (CDV) (n=4); VI - Control (saline) (n=5). PCL 016 and control rabbits are treated in both eyes 4 times daily for 7 days, while CDV rabbits are treated in both eyes twice daily for 7 days. All eyes are cultured for virus on days 0, 1, 3, 4, 5, 7, 9, 11, and 14[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 292.5±13.0 °C at 760 mmHg |
| Melting Point | 139-142 °C(lit.) |
| Molecular Formula | C6H5NO2 |
| Molecular Weight | 123.109 |
| Flash Point | 130.7±19.8 °C |
| Exact Mass | 123.032028 |
| PSA | 50.19000 |
| LogP | -0.10 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.571 |
| Storage condition | Store at RT. |
| Water Solubility | 887 g/L (20 ºC) |
Ulrica JiangTrade member
Hong Kong TianSheng new material trading Co., LTD.
Website：https://www.tianshengjt.com
Whatsapp：+86 17320697058
Email：ulrica@hktiansheng.com
Company Profile Introduction
We are a manufacturer and trader in China, with 10 years of experience in the export of chemical and pharmaceutical raw materials and 320 employees. We are all promoted on Made in China, chemical book, Google platform.
More than ten years of export experience Specializing in the production of pharmaceutical raw materials, odybuilding products, sexual enhancement products, local anesthesia products, best-selling pharmaceutical intermediates, etc. The quality of our products has reached the international leading level. Can provide free samples to provide testing. Provide product customization services.
We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful distributors and factories. Deliver the package as soon as possible.
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- Since:2021-08-12
- Address: UNIT 1307，BEVERLEY COMMERCIAL,CENTRE,87-105 CHATHAM ROAD,SOUTH TSIM SHA TSUI，KLN,HONG KONG