Remdesivi Intetmediate GS

Introduction:
GS-441524 is an adenosine nucleotide analog antiviral, similar to remdesivi.This molecule was patented in 2009. In vitro studies of GS-441524 have determined it has a higher EC50 than remdesivi against a number of viruses, meaning GS-441524 is less potent.GS-441524 continues to be studied in the treatment of Feline Infectious Peritonitis Virus,  that only infects cats.

Function:
GS-441524 is phosphorylated into nucleoside monophosphate (NMP) by cytokinase in cells, and then transformed into an active triphosphate metabolite (NTP structural analogue). In viral RNA synthesis, the active NTP analogues compete with the naturalnucleosides (ATP, TTP, CTP, GTP) to participate in RNA transcription. When gs-441524 is inserted into the transcription products, the transcription will be terminated in advance, thus inhibiting the viral RNA transcription process.When gs-441524 is inserted into the transcription products, the transcription will be terminated in advance, thus inhibiting the viral RNA transcription process.

TECHNICAL SPECIFICATIONS

STORAGE AND SAFETY
The product is a kind of white powder which is safe, nontoxic and harmless. Keep from moisture during transport and should be stored in a ventilated, dry place. To achieve best possible results, we recommend storage under the condition stated above and use within 12 months from production.  Avoid breathing dust when handling, and wash with soap & water in case of skin contact. For more details, please refer to the Material Safety Data Sheet.

APPLICATIONS
Powder coatings
Decorative architectural coatings-interior and exterior.
Marine and protective coatings
Solvent based printing ink
Water and solvent based industrial coatings
Plastics and rubber 
Decorative laminating base paper making
Other applications