34661-75-1
| Price | USD15.00 | USD12.00 |
| Packge | 1KG | 100KG |
- Min. Order:1KG
- Supply Ability:9000kg/per week
- Time:2022-05-20
Product Details
- Product NameUrapidil
- CAS No.34661-75-1
- EINECS No.252-130-4
- MFC20H29N5O3
- MW387.48
- Appearancepowder to crystalWhite to Light yellow to Light orange
- Melting point 156-158°
- Boiling point 513.42°C (rough estimate)
- density 1.2058 (rough estimate)
- storage temp. Sealed in dry,Room Temperature
Product Name | Treatment of hypertension Urapidil CAS:34661-75-1 |
CAS No | 34661-75-1 |
EINECS No | 252-130-4 |
Color | White powder |
Purity | 99% |
1. Various types of hypertension (1) Essential hypertension URA has a significant antihypertensive effect on essential hypertension, and URA has a more obvious reduction effect on systolic blood pressure, with minimal impact on heart rate and low incidence of adverse reactions, which can be tolerated by patients.
(2) After URA treatment,SBP, DBP and HR were significantly lower than before. And with the extension of medication time, the antihypertensive effect is more obvious, does not cause reflex tachycardia, compared with sodium nitroprusside, nitroglycerin and phentolamine antihypertensive drugs, this is the biggest advantage of URA.
(3) The antihypertensive effect of URA in hypertensive emergencies is quick and effective in treating hypertension caused by various causes. The symptoms of patients in THE URA group were better, and the side effects such as orthostatic hypotension, complexion flushing and palpitation were observed in the phentolamine group.
(4) α1 receptor of pulmonary hypertension is widely present in pulmonary vascular bed. URA blocks α1 receptor, reduces pulmonary artery pressure, avoids vascular dilation in hypoxic zone, and does not aggravate functional arteriovenous shunt, so as to maintain or increase arterial partial pressure. The results showed that the total effective rate of URA in the treatment of pulmonary hypertension, heart failure and pulmonary heart disease was 91.66%,P(O2) increased by 25.31%, and the mean pulmonary artery pressure and pulmonary hair impaction pressure decreased by 28.74% and 35.62%, respectively. At the same time, the product of systolic blood pressure and heart rate also decreased, reflecting the decrease of oxygen consumption of myocardium, which is conducive to the protection of myocardium.
(1) Acute left heart failure URA25mg plus normal saline 10mL, IV,5min. After that, urA112.5mg and 5% glucose 500mL were dropped intravenously. Results URA significantly reduced SBP,DBP and HR and SBP and HR in patients with acute left heart failure. Blood pressure decreased significantly 5-15 min after administration, and reached the lowest point at 60min, with SBP and DBP decreased 26.8% and 24.6%, respectively, compared with before administration. Most of the left ventricular systolic function was significantly improved. It has been reported that URA is significantly better than nitroglycerin in the treatment of acute left heart failure, with an overall response rate of 97% for URA and 80% for nitroglycerin in 69 patients. And the side effects of URA are small.
(2) congestive heart failure (CHF)URA12.5 ~ 25mg+ normal saline 20mL,iv,3 ~ 5min, followed by 50 ~ 100mgURA+5% glucose 250 ~ 500mL iv. Results URA improved the effective rate of cardiac function in patients with congestive heart failure up to 92%, and the clinical symptoms were significantly improved. Meanwhile, URA directly dilated renal vessels, increased renal vascular perfusion, improved renal function, and decreased blood and urine β 2-Mg after heart failure correction.
Packing & Shipping
| Quantity(Metric Tons) | 1 - 1 | 2 - 20 | >20 |
| Est. Time(days) | 10 | 25 | To be negotiated |
Hebei Lingding Biotechnology Co., Ltd. is a professional business company ,that include pharmaceutical raw materials, pharmaceutical intermediates,and other more than 1000 products of the enterprise, The registered capital is 3 million yuan, it is a collection of scientific research, production and sales in one of the enterprises.
Since its establishment, the company has always adhered to the core concept of "focus on products, attentive service", adhere to the business purpose of "innovation, professional, win-win", to provide customers with a full range of meticulous and thoughtful services. We will adhere to the customer's serious and responsible attitude, comply with the standardized operation procedures, with efficient execution to complete customer needs.
The company's products are sold all over the world, mainly exported to the United States, Europe, Southeast Asia, Australia, the Middle East and South Africa and other countries.The company has a strong scientific research and technical team, can provide customers with high quality products and a full range of services. We will provide first-class products and better service to face the needs of customers, to meet the challenges of the market. Welcome domestic and foreign customers to negotiate.
Our Services
1.Any inquiry or message will be replied within 12 hours.
2.Professional manufacturer. Welcome to visit our website.
3.API, Intermediate are available, we can offer Custom Synthesis, and registration as well.
4.Fast delivery.
5.After-sale services
FAQ
Q1. Are you a manufacturer?
Answer: Yes, we have our own factory.
Q2. Do you have GMP or DMF?
Answer: Yes, we have GMP certificate for some products, and we can provide DMF as well.
Q3. What information should I let you know if I want to get a quotation?
Answer: -Quality you require, eg. Assay, Purity, or single impurity
-Quantity you need
-Standard you want, such as USP, EP, JP etc.
Q4. How to make the payment?
Answer: T/T in advance are highly recommended. We can accept Western Union,
Money Gram and Paypal as well.
Q5. When will you deliver the goods?
Answer: For sample(less than 1kg), in about 3 working days after payment; for larger orders (more than 1kg), in about 7 working days after payment.
Q6. How will you deliver the goods?
Answer: We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air Post. For container products, we can do sea shipping. You also can choose your own shipping forwarder.
Q7. When will we receive the goods?
Answer: For samples, we will send by TNT/DHL/FEDEX/UPS express, usually it takes about 3-5 to reach you; for larger orders, it will take about 7 -10days at most.
Q8. What if we find your products unsatisfied?
Answer: We will send you a COA (Certificate of Analysis) to you first for you to confirm the quality, but if you find our products not confirm with the COA after you receive it, please show us your test result, we will refund you once we confirm that.
Q9.Do you have stock?
Answer:As we know,most customers prefer stock,so we will try to keep stock for some products.
Company Profile Introduction
Hebei Lingding Biotechnology Co., Ltd. is a professional business company ，that include pharmaceutical raw materials, pharmaceutical intermediates,and other more than 1000 products of the enterprise, The registered capital is 3 million yuan, it is a collection of scientific research, production and sales in one of the enterprises.
Since its establishment, the company has always adhered to the core concept of "focus on products, attentive service", adhere to the business purpose of "innovation, professional, win-win", to provide customers with a full range of meticulous and thoughtful services. We will adhere to the customer's serious and responsible attitude, comply with the standardized operation procedures, with efficient execution to complete customer needs.
The company's products are sold all over the world, mainly exported to the United States, Europe, Southeast Asia, Australia, the Middle East and South Africa and other countries.The company has a strong scientific research and technical team, can provide customers with high quality products and a full range of services. We will provide first-class products and better service to face the needs of customers, to meet the challenges of the market. Welcome domestic and foreign customers to negotiate.
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- Inquiry
- 2024-02-21
- Since:2021-03-01
- Address: Room 1810, Future Time Business Building, 121 Zhongshan West Road, Qiaoxi Dist.