Specifications
Food  Grade:

Pharmaceutical Grade:

L-Proline is one of important amino acids which form protein in human boby. It is the essential material of amino acid transfusion. And it is also the main intermediate for compounding Captopril, Enalapril and other antihypertensive drugs. It has been widely used in food, medicine and other industries. It is made by fermentation of corn. So it is more safer.

1. Used as nutritional supplement.
2. Used as the materials of compound amino acid infusion. Used in malnutrition, protein deficiency disease, stomach disease, scald and protein supplement after surgery.

There are two kinds of L - proline. One is direct fermentation, using glucose and yellow short bacillus mutant or glutamic acid bacillus wild strains, L - proline obtained with microbial fermentation; 2 it is chemical synthesis to glutamic acid as raw materials, and anhydrous ethanol under the sulfuric acid catalytic esterification, and add triethanolamine to amine sulfate free, glutamic acid - delta - ethyl ester. Reoccupy metal reductant glutamic acid  reduction - delta - ethyl ester, raw proline, finally the purification can be rough on the proline. Small craft take L - glutamic acid esterification said 147 g, into three bottle neck, add 1 L, anhydrous ethanol mix cool to 0 ºC, and then add 80 ml - H2SO4, at 0-5 ºC stirring reaction 1 h, 1 h at room temperature to continue response, response all clear. Under 20 ºC and to pH 8-8.5, precipitation white crystalline, 1 h at room temperature and stirring, let stand for 5 ºC cooling filtration, crystallization, washing with 95% ethanol, drained after vacuum drying, to glutamic acid ethyl - delta - about 141 g. Melting point of 178-180 ºC, the yield of 80% 83%. [alpha] 32 + 29.8 d (C = 1 g/ml 10% HCl). Reduction in three flask into glutamic acid ethyl - delta - 175 g, add distilled water, 875 ml, stir cool to 5 ºC, add in another KBH4 53.9 g, about 1 h adds, at room temperature and 1 h reaction, heat preservation 50 ºC reaction 3 h. Cooled to 0 ºC, add 6 mol/L HCl to pH4, filtering the filtrate, quick rough L - proline aqueous solution. Ion exchange resin - alumina column chromatography separation and purification raw will L - proline aqueous solution, with 4 ml/min flow entering into the 732 - H + resin exchange column charge 10 ml acid resin (1 g). First rinse with distilled water to neutral, then use 1 mol/L  elution, collection of L - containing proline eluent (thin layer chromatography with silica gel G control). Condensed the eluent decompression to dry, then use a small amount of water dissolves, it into neutral alumina column, again with 60% ethanol elution solution (or a thin layer chromatography with silica gel G control).  

About US

Our company is a hi-tech enterprise integrating R & D, production, agency and sales of fine chemicals such as inorganic chemicals, organic chemicals, flavors and fragrances, pharmaceutical raw materials and intermediates. We have established long-term cooperation with many large group companies at home and abroad.

FAQ:

Q1: Can i get some samples?

A: Yes, we can supply the sample, but the shipping cost be paid by our customers.

Q2: How to start orders or make payments?

A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union or Paypal and so on.

Q3: How to confirm the Product Quality before placing orders?

A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q4:What's your MOQ?

A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Q5: How about delivery lead time?

A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)