Repaglinide powder

Repaglinide is a kind of diabetes treatment drug, which belongs to non-sulfonylurea insulin releasing agent. It was successfully developed by German BoehringerIngelheim Company and approved by THE US FDA in December 1997. In 1998, repaglinide was successively marketed in the US and European countries under the trade name Nohedrone, which is mainly used for the treatment of dietary control Weight loss and exercise are not effective in controlling hyperglycemia in patients with type 2 diabetes (non-insulin-dependent) NovoNordisk's replaglinide+metforminHCl (PrandiMet) tablet was approved by the FDA in 2008 for the treatment of type 2 diabetes In terms of chemical structure, repaglinide derivatives of carbamyl methylbenzenic acid are a kind of fast acting and short acting time insulin secreting glucose regulator during meals. Its mechanism of action is mainly through closing the potassium channel on β cell membrane, resulting in the influx of calcium ions, and the increase of intracellular calcium ion concentration, thus stimulating insulin secretion However, the receptor sites are different from those of sulfonylureas, and the drugs do not enter β cells, inhibit protein synthesis or directly cause exocytosis of insulin. The absorption and metabolism of the drugs are rapid, and the peak and half-life of the drugs are about 1 hour. After taking the drugs, the plasma insulin concentration increases rapidly and significantly, leading to a significant decrease in blood glucose Therefore, the method of taking this drug is to take it with meals and not with meals, which is the so-called blood glucose regulator with meals. Each dose is 0.25g and 2g. The flexible way of taking the drug can reduce hypoglycemia caused by missed meals and delayed meals, and after taking the drug for six months, the postprandial blood glucose can be reduced by 6mmol/L, fasting blood glucose can be reduced by 4mmol/L, and HbAlc2% can be reduced. Repaglinide is as effective as metformin in obese patients with type 2 diabetes, better with metformin than with metformin alone Safety studies showed no severe hypoglycemia and liver damage, few drug interactions, and well tolerated by patients

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Company Information

   Hebei Lingding Biotechnology Co., Ltd. is a professional business company ,that include pharmaceutical raw materials, pharmaceutical intermediates,and other more than 1000 products of the enterprise,  The registered capital is 3 million yuan, it is a collection of scientific research, production and sales in one of the enterprises.

Since its establishment, the company has always adhered to the core concept of "focus on products, attentive service", adhere to the business purpose of "innovation, professional, win-win", to provide customers with a full range of meticulous and thoughtful services. We will adhere to the customer's serious and responsible attitude, comply with the standardized operation procedures, with efficient execution to complete customer needs.

The company's products are sold all over the world, mainly exported to the United States, Europe, Southeast Asia, Australia, the Middle East and South Africa and other countries.The company has a strong scientific research and technical team, can provide customers with high quality products and a full range of services. We will provide first-class products and better service to face the needs of customers, to meet the challenges of the market.  Welcome domestic and foreign customers to negotiate.
Our Services
 1.Any inquiry or message will be replied within 12 hours.
 2.Professional manufacturer. Welcome to visit our website.
 3.API, Intermediate are available, we can offer Custom Synthesis, and registration as well.
 4.Fast delivery.
 5.After-sale services
FAQ
 Q1. Are you a manufacturer?
Answer: Yes, we have our own factory.

Q2. Do you have GMP or DMF?
Answer: Yes, we have GMP certificate for some products, and we can provide DMF as well.

Q3. What information should I let you know if I want to get a quotation?
Answer: -Quality you require, eg. Assay, Purity, or single impurity
-Quantity you need
-Standard you want, such as USP, EP, JP etc.

Q4. How to make the payment?
Answer: T/T in advance are highly recommended. We can accept Western Union,
Money Gram and Paypal as well.

Q5. When will you deliver the goods?
Answer: For sample(less than 1kg), in about 3 working days after payment; for larger orders (more than 1kg), in about 7 working days after payment.

Q6. How will you deliver the goods?
Answer: We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air Post. For container products, we can do sea shipping. You also can choose your own shipping forwarder.

Q7. When will we receive the goods?
Answer: For samples, we will send by TNT/DHL/FEDEX/UPS express, usually it takes about 3-5 to reach you; for larger orders, it will take about 7 -10days at most.

Q8. What if we find your products unsatisfied?
Answer: We will send you a COA (Certificate of Analysis) to you first for you to confirm the quality, but if you find our products not confirm with the COA after you receive it, please show us your test result, we will refund you once we confirm that.
 
Q9.Do you have stock?
Answer:As we know,most customers prefer stock,so we will try to keep stock for some products.