| Product Name | Evodiamine |
| CAS | 518-17-2 |
| Grade | Phamaceutical Grade |
| Color | Light yellow crystalline powder |
| Purity | 99% |
| Shelf life | 2 years |
Evodia rutaecarpa alkali is a kind of natural existence of indole alkaloids, is also a main biological active ingredients of traditional Chinese medicine evodia rutaecarpa Have elevated blood pressure effect antitumor protect the heart weight anti-inflammatory analgesic against alzheimer's disease and other pharmacological activities Evodia rutaecarpa alkali as natural anti-cancer drugs, inhibits the proliferation of many kinds of tumor cells, including cervical cancer colon cancer, lung cancer melanoma T lymphocyte leukemia Prostate and breast cancer and so on the many kinds of tumor cell proliferation inhibition of also have other biological activities, such as regulating body temperature anti oxygen dermatology application bronchoconstriction and hormone secretion regulation, etc In addition, evodia base for a variety of protein has good combining ability, thus can be used as target compounds play a variety of biological activities
1. Anti-tumor activity: Evodogine can inhibit the proliferation of a variety of tumor cells, including cervical cancer, colon cancer, lung cancer, melanoma, T-lymphocyte-like leukemia, prostate cancer, breast cancer and other tumor cells Studies have shown that evodogine promotes apoptosis by inhibiting the expression of related genes regulated by nuclear factor κB, such as the CycD1 apoptosis suppressor protein Bcl-2 Bcl-XL In addition, evodia rutaecarpa alkali can increase the apoptosis factors Bax expression and reduce the expression of apoptosis inhibiting factor the Bcl - 2, and specificity of cysteine protease to aspartic acid induced by apoptosis At the same time, in the process of evodia rutaecarpa alkali induction of apoptosis, reactive oxygen species and NO of p53, p21 protein tyrosine kinases and other proteins have the adjustment Phosphatidylinositol 3-kinase/protein kinase B and extracellular signal-regulated protein kinase signaling pathways also play an important role in the apoptosis of tumor cells induced by rucoridine. In addition to its anti-proliferation and anti-apoptosis effects, rucoridine also inhibits tumor invasion and metastasis 2. Alzheimer's disease (AD), also known as alzheimer's disease, is a progressive and irreversible brain disease mainly caused by synaptic degeneration and the death of nerve cells, resulting in cognitive, memory and behavioral impairment Further studies showed that wucorzine increased glucose uptake in brain tissues and inhibited the expression of inflammatory cytokines such as interleukin-1 β interleukin-6 tumor necrosis factor α and cyclooxygenase 2 in mouse AD models, but had no effect on amyloid β deposition Evodia rutaecarpa alkali, therefore, to improve the role of AD rat model behavior was considered by inhibiting inflammation play function results show that hydrogen to evodia rutaecarpa alkali as the same type of evodia rutaecarpa alkali, show the AD more effective use of biology, to hydrogen evodia rutaecarpa alkali chemical structure has been used in clinical research and development of new cholinesterase inhibitor 3. Effects on endocrine System Rutacorine can directly affect the fine reticulum of adrenal cortex in rats by decreasing the activity of intracellular adenosine phosphate (cAMP) related pathway, inhibiting the activity of 3β -hydroxysteroid dehydrogenase (3β-HSD) and other steroid hormone-producing enzymes, and decreasing and affecting the expression of signal transduction and RNA activated protein (StAR) Cell inhibition of corticosterone secretion 10-4mol·L-1 In rat testicular mesenchymal cells (TICs) incubated with evodogine for 124h effectively reduced the basic level of testosterone and the secretion of human chorionic gonadotropin-stimulated testosterone, and inhibited the release of testosterone induced by fursstrin Evodogine also inhibited testosterone release induced by 8-Br-camp and androstenedione 4. After 13 weeks of intervention, the body weight and Lee's index of obese rats were decreased, visceral fat weight and visceral fat weight index were decreased, and serum total cholesterol and triglyceride contents of obese rats were decreased. Compared with normal rats, the expression of transient voltage receptor cationic channel (TRPV1) in thoracic aorta tissue and DRG was decreased in obese rats, and increased CGRP in serum and abdominal aorta could increase the expression of TRPV1 in thoracic aorta tissue and DRG. Evodogine can reduce the content of CGRP in serum and abdominal aorta, and its mechanism may be related to regulating the expression of CGRP and TRPV1 in serum vascular tissue and DRG 5. The anti-inflammatory and analgesic effects of rutacorine can dose-dependently inhibit the expression of cyclooxygenase (COX-2) and nitric oxide synthase (iNOS), reduce the release of prostaglandin (E2) and block hypoxic-induced AKt Phosphorylation of 70kDa ribosomal protein S6 kinase (p70S6K) and 4E-binding protein (4E-BP) regulates hypoxic inducible factor (HIF-1alpha) translation and has no effect on mRNA level and protein degradation rate These results suggest that evodogine inhibits hypoxia-induced COX-2 expression mainly by mediating the dephosphorylation of Akt and p70S6K Rutaine significantly inhibited the number of writhing induced by acetic acid, and the isolated ileum of mice given rutaine lost the response to sensory nerve stimulation, but retained the response to vagus nerve stimulation. Rutaine exerted analgesic effect through sensory nerve desensitization 6. Effects on the cardiovascular system (1) on cardiac function in vitro evodia rutaecarpa alkali low concentration can accelerate the guinea pig heart tissue spontaneous rhythms, increase the contractile force, high concentration, on the contrary, when the inhibition enhanced under the condition of help induce calcium overload, indicates that the drugs on the guinea pigs in vitro heart tissue can produce the effect of the excitement of indirect and direct control Myocyte ischemia reperfusion and the damage caused by cardiac arrest, resistance to ischemic arrhythmias, and stimulate the release of endogenous CGRP in (2) affect the blood pressure of evodia rutaecarpa alkali antihypertensive effect by diastolic endothelial cells and smooth muscle cells, inhibits in steroid synthesis of aldosterone 11 - hydroxylase activity to influence the release of aldosterone, in turn, affects the blood pressure Evodia rutaecarpa methanol extracts and three kinds of quinolone alkaloids can obviously inhibit the angiotensin and rat liver membrane receptor, to a certain extent explain evodia rutaecarpa adjust blood pressure efficacy (3) diastolic blood vessels of evodia rutaecarpa alkali diastolic blood vessel function and endothelial activation and inhibition of vascular smooth muscle Ca2 + channel receptor mediated in related, but there are differences between the effect on different vessels Evodogine induces non-vascular endothis-dependent, concentration-dependent relaxation in the rabbit spongiform, which is related to the activation of QD channels and non-selective influence of phosphodiesterase to prevent cyclic nucleotide decomposition
Packaging & Shipping
| Quantity(Metric Tons) | 1 - 1 | 2 - 20 | >20 |
| Est. Time(days) | 10 | 25 | To be negotiated |
Company Information
Hebei Lingding Biotechnology Co., Ltd. is a professional business company ,that include pharmaceutical raw materials, pharmaceutical intermediates,and other more than 1000 products of the enterprise, The registered capital is 3 million yuan, it is a collection of scientific research, production and sales in one of the enterprises.
Since its establishment, the company has always adhered to the core concept of "focus on products, attentive service", adhere to the business purpose of "innovation, professional, win-win", to provide customers with a full range of meticulous and thoughtful services. We will adhere to the customer's serious and responsible attitude, comply with the standardized operation procedures, with efficient execution to complete customer needs.
The company's products are sold all over the world, mainly exported to the United States, Europe, Southeast Asia, Australia, the Middle East and South Africa and other countries.The company has a strong scientific research and technical team, can provide customers with high quality products and a full range of services. We will provide first-class products and better service to face the needs of customers, to meet the challenges of the market. Welcome domestic and foreign customers to negotiate.
Our Services
1.Any inquiry or message will be replied within 12 hours.
2.Professional manufacturer. Welcome to visit our website.
3.API, Intermediate are available, we can offer Custom Synthesis, and registration as well.
4.Fast delivery.
5.After-sale services
FAQ
Q1. Are you a manufacturer?
Answer: Yes, we have our own factory.
Q2. Do you have GMP or DMF?
Answer: Yes, we have GMP certificate for some products, and we can provide DMF as well.
Q3. What information should I let you know if I want to get a quotation?
Answer: -Quality you require, eg. Assay, Purity, or single impurity
-Quantity you need
-Standard you want, such as USP, EP, JP etc.
Q4. How to make the payment?
Answer: T/T in advance are highly recommended. We can accept Western Union,
Money Gram and Paypal as well.
Q5. When will you deliver the goods?
Answer: For sample(less than 1kg), in about 3 working days after payment; for larger orders (more than 1kg), in about 7 working days after payment.
Q6. How will you deliver the goods?
Answer: We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air Post. For container products, we can do sea shipping. You also can choose your own shipping forwarder.
Q7. When will we receive the goods?
Answer: For samples, we will send by TNT/DHL/FEDEX/UPS express, usually it takes about 3-5 to reach you; for larger orders, it will take about 7 -10days at most.
Q8. What if we find your products unsatisfied?
Answer: We will send you a COA (Certificate of Analysis) to you first for you to confirm the quality, but if you find our products not confirm with the COA after you receive it, please show us your test result, we will refund you once we confirm that.
Q9.Do you have stock?
Answer:As we know,most customers prefer stock,so we will try to keep stock for some products.
