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Adapalene is a new naphthoic acid derivatives developed by the French company Galdeama Laboratories. It was first marketed in France in June 1996 under the trade name "Differin" and is mainly used to improve inflammatory skin lesions and regulate hair follicles , Sebaceous gland epithelial cell differentiation and acne treatment.
Adapalene is a retinoid that has been shown to have anti-inflammatory properties in in vivo and in vitro inflammatory models, is chemically stable, does not decompose readily in air and light. The mechanism of action is the same as that of retinoic acid and binds to specific retinoid receptors, with the difference that adapalene does not bind to protein-bound cytoplasmic receptors. Dermatological testing in animal models established in mice has demonstrated that adapalene can treat acne and also has an effect on acne vulgaris and the process of differentiation. The mechanism of action is to reduce the formation of small acne by normal differentiation of hair follicle cells. In standard in vitro and in vivo anti-inflammatory assays. Adaptant is superior to retinoid acid in that it inhibits the chemotactic response of human polymorphonuclear leukocytes and inhibits the metabolism of polymorphic nucleocapsids by inhibiting the conversion of arachidonic acid to adipogenic mediators via lipid oxidation , Thereby alleviating the inflammatory response mediated by cellular responses. Suitable for the treatment of acne vulgaris with acne vulgaris that acne, pimples and pustules are the main manifestations. It can also be used to treat acne on the face, chest and back.

It stimulates cell division in the skin and reduces the production of keratin. It aids skin peeling and prevents the formation of acne lesions (comedones). The action of adapalene combats the changes that take place in acne.
Adapalene is used in the treatment of mild to moderate acne. It is best suited to dry and fair skin.
Adapalene Powder is a white to off-white powder, very slightly soluble in ethanol, and practically insoluble in water. Adapalene has actions similar to vitamin A (retinol).
Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. It is effective against acne conditions where comedones are predominant.

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Company Information

   Hebei Lingding Biotechnology Co., Ltd. is a professional business company ,that include pharmaceutical raw materials, pharmaceutical intermediates,and other more than 1000 products of the enterprise,  The registered capital is 3 million yuan, it is a collection of scientific research, production and sales in one of the enterprises.

Since its establishment, the company has always adhered to the core concept of "focus on products, attentive service", adhere to the business purpose of "innovation, professional, win-win", to provide customers with a full range of meticulous and thoughtful services. We will adhere to the customer's serious and responsible attitude, comply with the standardized operation procedures, with efficient execution to complete customer needs.

The company's products are sold all over the world, mainly exported to the United States, Europe, Southeast Asia, Australia, the Middle East and South Africa and other countries.The company has a strong scientific research and technical team, can provide customers with high quality products and a full range of services. We will provide first-class products and better service to face the needs of customers, to meet the challenges of the market.  Welcome domestic and foreign customers to negotiate.

Our Services
 1.Any inquiry or message will be replied within 12 hours.
 2.Professional manufacturer. Welcome to visit our website.
 3.API, Intermediate are available, we can offer Custom Synthesis, and registration as well.
 4.Fast delivery.
 5.After-sale services
FAQ
 Q1. Are you a manufacturer?
Answer: Yes, we have our own factory.

Q2. Do you have GMP or DMF?
Answer: Yes, we have GMP certificate for some products, and we can provide DMF as well.

Q3. What information should I let you know if I want to get a quotation?
Answer: -Quality you require, eg. Assay, Purity, or single impurity
-Quantity you need
-Standard you want, such as USP, EP, JP etc.

Q4. How to make the payment?
Answer: T/T in advance are highly recommended. We can accept Western Union,
Money Gram and Paypal as well.

Q5. When will you deliver the goods?
Answer: For sample(less than 1kg), in about 3 working days after payment; for larger orders (more than 1kg), in about 7 working days after payment.

Q6. How will you deliver the goods?
Answer: We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air Post. For container products, we can do sea shipping. You also can choose your own shipping forwarder.

Q7. When will we receive the goods?
Answer: For samples, we will send by TNT/DHL/FEDEX/UPS express, usually it takes about 3-5 to reach you; for larger orders, it will take about 7 -10days at most.

Q8. What if we find your products unsatisfied?
Answer: We will send you a COA (Certificate of Analysis) to you first for you to confirm the quality, but if you find our products not confirm with the COA after you receive it, please show us your test result, we will refund you once we confirm that.
 
Q9.Do you have stock?
Answer:As we know,most customers prefer stock,so we will try to keep stock for some products.