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Homecompany58-14-0
Pyrimethamine
Pyrimethamine
Pyrimethamine
Pyrimethamine
Pyrimethamine
Pyrimethamine

58-14-0

Price USD85.00USD72.00
Packge 1KG100KG
  • Min. Order:1KG
  • Supply Ability:9000kg/per week
  • Time:2022-05-20

Product Details

  • Product NamePyrimethamine
  • CAS No.58-14-0
  • EINECS No.200-364-2
  • MFC12H13ClN4
  • MW248.71
  • AppearanceneatWhite to Off-White
  • Water Solubility <0.01 g/100 mL at 21 ºC
  • Melting point 233-234°C
  • storage temp. Keep in dark place,Inert atmosphere,Room temperature
  • Boiling point 393.35°C (rough estimate)
  • density 1.2171 (rough estimate)
Product NamePyrimethamine 
CAS58-14-0
Appearancewhite crystalline powder 
Molecular formulaC12H13ClN4
Shelf Life24 months when properly stored


This product can inhibit the dihydrofolate reductase of the plasmodium, thereby interfering with the normal generation of folic acid of the plasmodium. It is effective in the early stage of falciparum malaria and Plasmodium vivax erythrocytes. It is often used as a pathogenic preventive drug. In addition, it can also inhibit the development of malaria parasites in mosquitoes, so it can block transmission. It is clinically used to prevent malaria and anti-relapse treatment during resting period.
Pyrimethamine is a diaminopyrimidine which is structurally related to trimethoprim. It is effective against erythrocytic stage of Plasmodium (P) falciparum and less so against P. vivax, P. ovale and P. malariae. Pyrimethamine also inhibits the sporogony in the mosquito, resulting in a decrease of transmission of the infection within the community.
The mechanism of action of pyrimethamine is related to its inhibition of dihydrofolic reductase necessary for the folic acid synthesis in the parasite. Pyrimethamine acts slowly and is not recommended as monotherapy for acute malaria attacks. Resistance to pyrimethamine developed soon when the drug was used on a large scale as monoprophylaxis. In resistant strains, the enzyme dihydrofolic reductase binds to pyrimethamine several hundred times less than in sensitive strains. This high grade resistance is probably a onestep mutation and cannot be overcome by increasing the dose. However, when combined with long-acting sulphonomides (sulphadoxine), the effect of pyrimethamine is potentiated and the risk of developing resistant strains is far less.

Packaging & Shipping

Quantity(Metric Tons)1 - 12 - 20>20
Est. Time(days)1025To be negotiated


Fine Chemicals Hexyl Chloroformate, CAS: 6092-54-2Fine Chemicals Hexyl Chloroformate, CAS: 6092-54-2Fine Chemicals Hexyl Chloroformate, CAS: 6092-54-2

Company Information

   Hebei Lingding Biotechnology Co., Ltd. is a professional business company ,that include pharmaceutical raw materials, pharmaceutical intermediates,and other more than 1000 products of the enterprise,  The registered capital is 3 million yuan, it is a collection of scientific research, production and sales in one of the enterprises.

Since its establishment, the company has always adhered to the core concept of "focus on products, attentive service", adhere to the business purpose of "innovation, professional, win-win", to provide customers with a full range of meticulous and thoughtful services. We will adhere to the customer's serious and responsible attitude, comply with the standardized operation procedures, with efficient execution to complete customer needs.

The company's products are sold all over the world, mainly exported to the United States, Europe, Southeast Asia, Australia, the Middle East and South Africa and other countries.The company has a strong scientific research and technical team, can provide customers with high quality products and a full range of services. We will provide first-class products and better service to face the needs of customers, to meet the challenges of the market.  Welcome domestic and foreign customers to negotiate.

Our Services
 1.Any inquiry or message will be replied within 12 hours.
 2.Professional manufacturer. Welcome to visit our website.
 3.API, Intermediate are available, we can offer Custom Synthesis, and registration as well.
 4.Fast delivery.
 5.After-sale services
FAQ
 Q1. Are you a manufacturer?
Answer: Yes, we have our own factory.

Q2. Do you have GMP or DMF?
Answer: Yes, we have GMP certificate for some products, and we can provide DMF as well.

Q3. What information should I let you know if I want to get a quotation?
Answer: -Quality you require, eg. Assay, Purity, or single impurity
-Quantity you need
-Standard you want, such as USP, EP, JP etc.

Q4. How to make the payment?
Answer: T/T in advance are highly recommended. We can accept Western Union,
Money Gram and Paypal as well.

Q5. When will you deliver the goods?
Answer: For sample(less than 1kg), in about 3 working days after payment; for larger orders (more than 1kg), in about 7 working days after payment.

Q6. How will you deliver the goods?
Answer: We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air Post. For container products, we can do sea shipping. You also can choose your own shipping forwarder.

Q7. When will we receive the goods?
Answer: For samples, we will send by TNT/DHL/FEDEX/UPS express, usually it takes about 3-5 to reach you; for larger orders, it will take about 7 -10days at most.

Q8. What if we find your products unsatisfied?
Answer: We will send you a COA (Certificate of Analysis) to you first for you to confirm the quality, but if you find our products not confirm with the COA after you receive it, please show us your test result, we will refund you once we confirm that.
 
Q9.Do you have stock?
Answer:As we know,most customers prefer stock,so we will try to keep stock for some products.



Company Profile Introduction

Hebei Lingding Biotechnology Co., Ltd. is a professional business company ,that include pharmaceutical raw materials, pharmaceutical intermediates,and other more than 1000 products of the enterprise,  The registered capital is 3 million yuan, it is a collection of scientific research, production and sales in one of the enterprises.

Since its establishment, the company has always adhered to the core concept of "focus on products, attentive service", adhere to the business purpose of "innovation, professional, win-win", to provide customers with a full range of meticulous and thoughtful services. We will adhere to the customer's serious and responsible attitude, comply with the standardized operation procedures, with efficient execution to complete customer needs.

The company's products are sold all over the world, mainly exported to the United States, Europe, Southeast Asia, Australia, the Middle East and South Africa and other countries.The company has a strong scientific research and technical team, can provide customers with high quality products and a full range of services. We will provide first-class products and better service to face the needs of customers, to meet the challenges of the market.  Welcome domestic and foreign customers to negotiate.

 

  • Since:2021-03-01
  • Address: Room 1810, Future Time Business Building, 121 Zhongshan West Road, Qiaoxi Dist.
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