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HomecompanyObeticholic Acid
Obeticholic Acid

Obeticholic Acid

Price Get Latest Price
Packge 25Kg/Bag
  • Min. Order:2Kg/Bag
  • Supply Ability:20 tons
  • Time:2022-06-10

Product Details

  • Product NameObeticholic Acid
  • CAS No.459789-99-2
  • EINECS No.810-245-2
  • MFC26H44O4
  • MW420.63
  • AppearanceWhite solid.White
  • density 1.091
  • Melting point 108-110 °C
  • Boiling point 562.9±25.0 °C(Predicted)
  • storage temp. -20°C

Product Information

Obeticholic acid is a semi-synthetic bile acid analogue and acts as a farnesoid-X receptor (FXR) agonist. It is used for the treatment of primary biliary cholangitis. It is also under investigation for the treatment of other liver diseases,primary biliary cirrhosis, bile acid diarrhea and related disorders. Study has shown that it also has potential for treating nonalcoholicsteatohepatitis (NASH), and portal hypertension. Obeticholic acid takes effect through acting s the agonist of the farnesoid X receptor (FXR), which is the regulator of bile and cholesterol metabolism in the liver.

Items                                                              

Standard

Appearance

White powder

Water

Not more than 2.0%      

Residue on ignition

Not more than 0.2%

Heavy Metals

Not more than 20ppm

Related Substances

Any other impurity:Not more than 0.3%                                    

Total impurities:Not more than 1.0%

Residual Solvents

Methanol:Not more than 0.3%

Ethaonl:Not more than 0.5%

Butyl acetate:Not more than 0.5%

N-heptane:Not more than 0.5%

Assay

99.2%

Usage

Obeticholic acid is also called 6-Ethylchenodeoxycholic acid. It is a new derivative of chenodeoxycholic acid (CDCA) in human primary bile acids, a natural ligand for farnesoid x receptors (FXR). Obeticholic acid was developed by American pharmaceutical company Intercept as the first drug to treat cholestatic liver disease in 20 years, and it is administered on patients that do not respond well to or cannot tolerate the old standard treatment drug ursodeoxycholic acid. Obeticholic acid has also been tested to treat a more common form of fatty liver – non-alcoholic fatty liver disease (NAFLD). Obeticholic acid can also be developed to treat other liver and intestine diseases.


Cmpany Information



Company Profile Introduction

Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of pharmaceutical intermediates, APIs, health and food supplements, cosmetic raw materials, herbal extracts, polypeptides and prostaglandin derivatives, etc.. We have passed ISO9001:2015. With qualified products, competitive price and excellent service, we have received great reputation of our customers from all over the world, including Southeast Asia, Europe, North America, South America, Middle East and other countries. We have over 20 years good partners in Japan、Korea and Switzerland. Sinoway has a professional R&D team. We have built close cooperative relationships with many research institutes and universities in China. Moreover, Sinoway combines market analysis with technology, providing new business trends to our clients. In addition, we have very close cooperation relationships with many Chinese pharmaceutical factories. These pharmaceutical manufacturers have GMP regulated workshops, advanced production and testing equipments, first-class QC labs and a production team with rich experience. We can supply various Active Pharmaceutical Ingredients and finished products which meet EP/USP/BP standards. Chinese GMP, EU-GMP, COS/CEP certificates with DMF documents are available, and many products have been approved by FDA. We believe that quality and innovation are vital for an enterprise. Adhering to the business philosophy of integrity and win-win cooperation, Sinoway is looking forward to have a bright future with you together.
  • Since:1996-07-16
  • Address: Fujian China ,16F, Huicheng Comm. Complex, 839 Xiahe RD.
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