Obeticholic Acid
Price | Get Latest Price | ||
Packge | 25Kg/Bag |
- Min. Order:2Kg/Bag
- Supply Ability:20 tons
- Time:2022-06-10
Product Details
- Product NameObeticholic Acid
- CAS No.459789-99-2
- EINECS No.810-245-2
- MFC26H44O4
- MW420.63
- AppearanceWhite solid.White
- density 1.091
- Melting point 108-110 °C
- Boiling point 562.9±25.0 °C(Predicted)
- storage temp. -20°C
Product Information
Obeticholic acid is a semi-synthetic bile acid analogue and acts as a farnesoid-X receptor (FXR) agonist. It is used for the treatment of primary biliary cholangitis. It is also under investigation for the treatment of other liver diseases,primary biliary cirrhosis, bile acid diarrhea and related disorders. Study has shown that it also has potential for treating nonalcoholicsteatohepatitis (NASH), and portal hypertension. Obeticholic acid takes effect through acting s the agonist of the farnesoid X receptor (FXR), which is the regulator of bile and cholesterol metabolism in the liver.
Items | Standard |
Appearance | White powder |
Water | Not more than 2.0% |
Residue on ignition | Not more than 0.2% |
Heavy Metals | Not more than 20ppm |
Related Substances | Any other impurity:Not more than 0.3% Total impurities:Not more than 1.0% |
Residual Solvents | Methanol:Not more than 0.3% Ethaonl:Not more than 0.5% Butyl acetate:Not more than 0.5% N-heptane:Not more than 0.5% |
Assay | 99.2% |
Usage
Obeticholic acid is also called 6-Ethylchenodeoxycholic acid. It is a new derivative of chenodeoxycholic acid (CDCA) in human primary bile acids, a natural ligand for farnesoid x receptors (FXR). Obeticholic acid was developed by American pharmaceutical company Intercept as the first drug to treat cholestatic liver disease in 20 years, and it is administered on patients that do not respond well to or cannot tolerate the old standard treatment drug ursodeoxycholic acid. Obeticholic acid has also been tested to treat a more common form of fatty liver – non-alcoholic fatty liver disease (NAFLD). Obeticholic acid can also be developed to treat other liver and intestine diseases.
Cmpany Information
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- Since:1996-07-16
- Address: Fujian China ,16F, Huicheng Comm. Complex, 839 Xiahe RD.