Ezetimibe
Price | Get Latest Price | ||
Packge | 25Kg/Bag |
- Min. Order:2Kg/Bag
- Supply Ability:20 tons
- Time:2022-06-10
Product Details
- Product NameEzetimibe
- CAS No.163222-33-1
- EINECS No.682-606-0
- MFC24H21F2NO3
- MW409.43
- AppearancepowderWhite or off-white
- Melting point 164-166°C
- storage temp. 2-8°C
- Boiling point 654.9±55.0 °C(Predicted)
- density 1.334±0.06 g/cm3(Predicted)
Product Information
Product name | Ezetimibe |
CAS No. | 163222-33-1 |
Molecular Formula | C24H21F2NO3 |
Molecular Weight | 409.43 |
Quality Standard | 98% up by HPLC, GMP,DMF,CEP |
Appearance | White powder |
Usage
Function of Ezetimibe
Ezetimibe is ananti-hyperlipidemic drug used for lowering the plasma cholesterol levels. It is indicated as an adjunctive therapy to diet for the reduction of high-level total-C, LDL-C, and ApoB in patients suffering primary (heterozygous familial and non-familial) hypercholesterolemia. It is also used in combination therapy with HMG-CoA reductase inhibitors.Ezetimibe does not inhibit the cholesterol synthesis in the liver, or increase bile acid excretion.Instead, ezetimibe takes effect throughacting at the brush border of the small intestine and inhibiting the absorption of cholesterol, further leading to a decrease in the delivery of intestinal cholesterol to the liver, This causes a reduction of hepatic cholesterol stores and an increase in clearance of blood cholesterol.
COA of Ezetimibe
ITEMS | SPECIFICATION | RESULT |
Appearance | White powder | Conforms |
Specific rotation | -25.0。~ -29.0。 | -26.2。 |
Melting range | 160。C ~167。C | 163。C~166。C |
Identity | Retention time: Similar to Reference Substance | Conforms |
IR: Similar to Reference Substance | Conforms | |
Chloride | ≤ 0.01% | Conforms |
Loss on drying | ≤ 0.5% | 0.11% |
Sulphated Ash | ≤ 0.1% | 0.01% |
Enantiomer | ≤ 0.15% | Undetected |
Diastereomer | ≤ 0.15% | Undetected |
Heavy metals | ≤ 10 ppm | Conforms |
Related substances | Single impurity ≤ 0.10% Total impurity ≤ 1.0% | 0.06% 0.2% |
Residual solvents | Methanol ≤ 3000ppm Isopropanol ≤ 5000ppm Chlorobenzene ≤ 360ppm | Undetected 351ppm Undetected |
Assay | 98.0~102.0%(calculated on the dried basis ) | 99.9% |
Conclusion | The results above meet all requirements under Ezetimibe in In-House Standard. |
Company Information
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- Since:1996-07-16
- Address: Fujian China ,16F, Huicheng Comm. Complex, 839 Xiahe RD.