Tetramisole hydrochloride 5086-74-8

Chemical property

Melting point: 266-267°C (lit.) 

Water solubility: 200g/L (20ºC) 

Merck13, 5480

BRN4358989

InChIKeyLAZPBGZRMVRFKY-UHFFFAOYSA-N

CAS database 5086-74-8 (CASDataBaseReference) 

safety information

Tetraimidazole hydrochloride use and synthesis method Physical and chemical properties Tetraimidazole hydrochloride, also known as DL -2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride, white crystalline powder, bitter and astringent, soluble in water and methanol, slightly soluble Ethanol, insoluble in acetone, is a highly effective, low-toxic, broad-spectrum veterinary anthelmintic. Uses Tetraimidazole hydrochloride is a biological response regulator with insect repellent activity. Insecticide (nematode); immune modulator. Biologically active Tetramisole is a mixture of right-handed and left-handed isomers, used as an insect repellent. In vitro studies Tetramisole is oral and non-toxic, and is tested in 14 different hosts with effective low-dose injections for all adult and juvenile gastrointestinal and lung nematodes. Tetramisole (10μg/mL) acts on the worm virus, causing continuous contraction of the isolated muscle. Tetramisole acts on the muscle of Ascaris lumbricoides, reducing its resting potential from 34mV to 10mV, and causing the previous high KTetramisole (0.1mM) to act on cats, directly or indirectly stimulating the muscles stimulated by the Chemicalbook, and enhancing the twitch response of the muscles. Tetramisole (0.1mM) acts on chickens to enhance the preparation of twitch response and reverse the inhibitory effect of Tubocurine, resulting in reversible neuromuscular block and muscle contracture. In vivo study Tetramisole (2mg/kg, i.v.) acts on cats. After a delay of 20 seconds, a strong contraction of the nictitating membrane is produced. A brief drop in blood pressure is followed by a continuous rise for up to 20 minutes. Tetramisole (2mg/kg) produced a greater contractile response than non-reserpine-treated cats. Tetramisole (5-10mg/kg, i.v.) acts on rabbits to cause a short-term sharp drop in blood pressure, which partially antagonizes atropine. After 3 weeks of treatment with Tetramisole (15mg/kg), the number of fecal nematode eggs in the flock began to increase and continued to rise to 12 weeks. Use as levamisole intermediate, antihelminthic safety information dangerous goods sign Xn, Xi dangerous category code 22-36/37/38-20/21/22 safety instructions 26-36WGKGermany3RTECS number NJ5950000 customs code 29349990 toxicity LD50inmice, rats( mg/kg): 22,24i.v.;84,130sc;210,480orally(Thienpoint)