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Ambrisentan
Ambrisentan

Ambrisentan 177036-94-1

Price USD254.00
Packge 10g/Bag
  • Min. Order:10KG
  • Supply Ability:10kg
  • Time:2022-03-18

Product Details

  • Product NameAmbrisentan
  • CAS No.177036-94-1
  • EINECS No.658-059-9
  • MFC22H22N2O4
  • MW378.42
  • AppearanceSolidWhite to Off-White
  • Melting point >150°C (dec.)
  • storage temp. Sealed in dry,2-8°C
  • Boiling point 551.1±60.0 °C(Predicted)
  • density 1.228±0.06 g/cm3(Predicted)

CAS: 177036-94-1

MF: C22H22N2O4

MW: 378.42

EINECS: 658-059-9

Melting point >150°C (dec.)

Boiling point 551.1±60.0 °C(Predicted)

density 1.228±0.06 g/cm3(Predicted)

storage temp. -20°C Freezer


Ambrisentan is a selective endothelin-A (ETA) receptor antagonist introduced for the oral treatment of patients with pulmonary arterial hypertension (PAH), to improve exercise capacity and delay clinical worsening. It is the third ET-receptor antagonist to be marketed for this indication behind bosentan and sitaxsentan. PAH is a rare disease of the small pulmonary arteries characterized by vascular proliferation and remodeling, resulting in a progressive increase in pulmonary vascular resistance and pulmonary arterial pressure, and ultimately, right ventricular failure and premature death. Early symptoms of PAH include gradual onset of shortness of breath, fatigue, palpitation, edema, and fainting. Endothelin-1 (ET-1), a potent vasoconstrictor and smooth muscle mitogen, is a key contributor to the acceleration of the disease, and its effects are mediated through activation ofETA and ETB receptors.



Company Profile Introduction

Baoji Guokang Bio-Technology Co., Ltd. has a subsidiary, Baoji Guokang Health Chemical Technology Co., Ltd.It is located in Baoji High-tech Zone,with epitomizing international, cooperative and honest. We are a young company full of action and energy, our profession improves us rapid progress, which satisfy our clients both in home and abroad. We are specialized in API's intermediates, fine chemicals and plant extracts.We toughly insist on that quality is always the most important item not only for us, but also for our clients. It is believed that we could be considered as the most powerful man in the area of ​​chemicals with combined strength in R&D and Marketing. We are a "customer first" company and believe that our success depends on double-wins.our customers are from more than 160 countries worldwide ,we work closely with every customer to support high quality business service. Our target purpose is "provide favorable value,convenient and flexible solutions for you."we promise: reasonable prices, short supplying period and satisfactory after-sales service. Buyers are welcome to contact us !

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  • Since:2008-05-08
  • Address: No.10,the 4th road of High-tech zone, Baoji City, Shaan’xi province, Mainland China
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