Product Details
- Product NameDoxorubicin hydrochloride
- CAS No.25316-40-9
- EINECS No.246-818-3
- MFC27H29NO11.ClH
- MW579.98
- Appearancesolidorange to dark red
- Melting point 216 °C (dec.)(lit.)
- storage temp. 2-8°C
- Water Solubility Soluble in water.
| Melting point | 216 °C (dec.)(lit.)
|
| alpha | D20 +248±2° (c = 0.1 in methanol) |
| storage temp. | 2-8°C
|
| solubility | H2O: 10 mg/mL, clear, red-orange
|
| pka | pKa 8.25±0.60 (Uncertain);8.43±0.70 (Uncertain);11.9±0.4 (Uncertain);12.95±0.1 (Uncertain);13.8±0.70 (Uncertain) |
| form | solid |
| color | orange to dark red |
| Water Solubility | Soluble in water. |
| λmax | 497nm(H2O)(lit.) |
| Merck | 14,3439 |
| BRN | 4229251 |
| Uses | Used as an antineoplastic |
| Uses | Strong fluorescent dye intercalating into DNA. Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA. Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent. |
| Uses | Antibacterial;DNA intercalant |
| Uses | Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently. |
| Uses | Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.[Cayman Chemical] |
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